- Research article
- Open Access
- Open Peer Review
Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer’s disease
© Maruff et al.; licensee BioMed Central Ltd. 2013
- Received: 5 July 2013
- Accepted: 16 December 2013
- Published: 23 December 2013
Previous studies have demonstrated the utility and sensitivity of the CogState Brief Battery (CBB) in detecting cognitive impairment in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and in assessing cognitive changes in the preclinical stages of AD. Thus, the CBB may be a useful screening tool to assist in the management of cognitive function in clinical settings. In this study, we aimed to determine the utility of the CBB in identifying the nature and magnitude of cognitive impairments in MCI and AD.
Healthy adults (n = 653) adults with amnestic MCI (n = 107), and adults with AD (n = 44) who completed the CBB participated in this study. Composite Psychomotor/Attention and Learning/Working Memory scores were computed from the individual CBB tests. Differences in composite scores were then examined between the three groups; and sensitivity and specificity analyses were conducted to determine cut scores for the composite scores that were optimal in identifying MCI- and AD-related cognitive impairment.
Large magnitude impairments in MCI (g = 2.2) and AD (g = 3.3) were identified for the learning/working memory composite, and smaller impairments were observed for the attention/psychomotor composite (g’s = 0.5 and 1, respectively). The cut-score associated with optimal sensitivity and specificity in identifying MCI-related cognitive impairment on the learning/working memory composite was -1SD, and in the AD group, this optimal value was -1.7SD. Both composite scores showed high test-retest reliability (r = 0.95) over four months. Poorer performance on the memory composite was also associated with worse performance on the Mini Mental State Exam and increasing severity on the Clinical Dementia Rating Scale sum of boxes score.
Results of this study suggest that the CogState learning/working memory composite score is reduced significantly in CI and AD, correlate well with measures of disease classification and are useful in identifying memory impairment related to MCI- and AD.
- Cognitive Impairment
- Mild Cognitive Impairment
- Composite Score
- Clinical Dementia Rate
- Amnestic Mild Cognitive Impairment
The importance of screening for dementia in individuals at risk of neurodegenerative diseases is now widely accepted (Snyder 2013). While advances in neuroimaging and fluid biomarkers show much promise for identifying early Alzheimer’s disease (AD), neuropsychological testing remains the cornerstone of early disease recognition (Albert et al. 2011; McKhann et al. 2011). Unfortunately, most neuropsychological test batteries shown to be sensitive to early AD require substantial time and expertise for both administration and scoring and this can limit their potential for use in wide-scale screening (Fredrickson et al. 2010). While some brief bedside cognitive screening instruments (i.e. measures that require less than 30 minutes for administration) such as the Mini Mental State Examination (MMSE) (Folstein et al. 1975) and Montreal Cognitive Assessment (MoCA) (Nasreddine et al. 2005) have been shown to be useful in case finding studies of AD and MCI, their relative lack of sensitivity to detecting subtle cognitive impairment has been well documented (McKhann et al. 2011; Proust-Lima et al. 2007) as has their potential for idiosyncratic errors in administration (Miller et al. 2008; Miller et al. 2011). Furthermore, although items on these bedside screening instruments are selected to assess a wide variety of cognitive domains, subscale scores on these instruments generally have low validity and reliability (Strauss et al. 2006).
The CogState Brief Battery (CBB) is a brief, computer-administered cognitive test battery that requires approximately 10 minutes for administration and consists of four cognitive tasks that measure psychomotor function, attention, working memory and memory (Darby et al. 2012; Fredrickson et al. 2010; Maruff et al. 2009). The sensitivity of the CBB to detect cognitive impairment in several neurodegenerative conditions has been demonstrated in prior work (Darby et al. 2009; Hammers et al. 2012; Lim et al. 2012a). Given that the CBB is computerized, the administration, scoring and reporting is automated and highly standardized. Each task in the battery is constructed using playing cards as stimuli with the test taker required to answer only “yes” or “no” on each trial in accord with a simple rule. The simple stimuli, rules and responses have been combined to generate cognitive paradigms that have been well-validated in neuropsychological and cognitive studies. These include measures of psychomotor function (Detection task), visual attention (Identification task), working memory (One Back task) and visual learning set within a pattern separation model (One Card Learning task, (Fredrickson et al. 2010; Maruff et al. 2009)). The simplicity of the CBB has allowed it to be applied successfully to the measurement of cognitive function in healthy older adults and in adults with clinically diagnosed and prodromal AD (Darby et al. 2009; Lim et al. 2012a, b). These studies have found that performance on the CBB working memory and learning tasks are sensitive to cognitive impairment in clinically diagnosed AD as well as its prodromal stage; amnestic MCI. Furthermore, the CBB was designed specifically for repeated administration, as it can be administered repeatedly without generating significant practice effects (Collie et al. 2003; Falleti et al. 2006), including in healthy older people (Fredrickson et al. 2010). The CBB has been shown to be sensitive to AD-related cognitive decline in healthy older adults and in adults with amnestic MCI (Darby et al. 2002 2012; Lim et al. 2013a, b) as well as to improvement in cognition arising from treatment with putative cognitive enhancing drugs such as donepezil (Jaeger et al. 2011), histamine H3 antagonists (Nathan et al. 2013) and testosterone (Davison et al. 2011) in older people.
Recent data from studies using the CBB suggests that composite scores, which are constructed from aggregating performance on the Detection and Identification tasks (i.e., an attention/psychomotor composite) and the learning and working memory tasks (i.e., a learning/working memory composite) may have greater sensitivity to both AD-related cognitive impairment and decline when compared to scores from the individual CBB tasks (Lim et al. in press 2012b, c). This increased sensitivity of cognitive composite scores over individual test scores is consistent with current neuropsychological models that emphasise the benefit of composite scores in clinical research (Nuechterlein et al. 2008).
While the CBB is not intended to replace formal neuropsychological assessment, the results of these recent studies do converge to suggest that it may be useful as a screening test for AD-related cognitive impairment in clinical settings. However, the clinical utility of the CBB in screening for AD-related cognitive impairment has not been established formally. To achieve this, it is necessary to compute estimates of sensitivity and specificity of each composite score and identify their optimal value for the identification of cognitive impairment related to both AD and MCI. It is also necessary to understand the nature of any relationship between each composite measure and cognitive impairment across disease severity. Finally, establishing the reliability and stability of these composite scores would facilitate the use of composite cognitive measures to monitor changes in cognitive function in clinical or prodromal AD.
The main aim of this study was to determine the sensitivity, specificity and reliability of the CBB composite scores for the detection and monitoring of cognitive impairment in aging and dementia (Lim et al. 2012a, b). The first hypothesis was that the attention/psychomotor and learning/working memory composites would be sensitive to AD-related cognitive impairment although the sensitivity of the learning/working memory composite would be greater than that of the attention/psychomotor composite. We then examined the relationship between each cognitive composite score and disease severity across the clinical groups. Our second hypothesis was that on reassessment, both cognitive composite scores would show high test-retest reliability and stability in healthy adults, amnestic MCI and AD.
Demographic and clinical characteristics for each clinical group
HC (n = 659)
MCI (n = 107)
AD (n = 51)
Education level med
One card learning accuracy*
One back accuracy*
Demographic and clinical characteristics
Participants underwent a series of comprehensive demographic, health and cognitive tests performed by trained research assistants under the supervision of licensed clinical neuropsychologists. Participants’ age was based on self-report, and this information was corroborated by a family member. Additionally, the MMSE, CDR, Wechsler Test of Adult Reading (WTAR) (Wechsler 2001) and the Hospital Anxiety and Depression Scale (HADS) (Snaith & Zigmond 1986) were administered to participants to measure overall cognitive impairment, general clinical function, premorbid IQ, and level of anxiety and depressive symptoms, respectively.
CogState brief battery
The four tasks from the CBB have been described in detail previously (Darby et al. 2012; Lim et al. 2012a, b), and they are summarized here. On each trial of each task, a single playing card stimulus was presented in the centre of the computer screen. The values, color and suit of the playing cards were determined by the requirements of each task. At the presentation of each playing card stimulus, participants were required to respond either “yes” or “no” by pressing a “yes” or “no” button attached to the computer through a USB port. The yes button was always placed on the right and pressed with the right hand and the no button was placed on the left and pressed with the left hand. Patients were instructed to press the “yes” or “no” button as quickly and as accurately as possible. At the beginning of each task, task rules were presented on the computer screen, and also given verbally to the participant by the supervisor. This was followed by an interactive demonstration in which participants practiced the task. Once the practice trials were complete, the task began. The four tasks were presented in the same order. For each task, the speed and accuracy of each response to each trial was recorded and expressed as a mean reaction time (in milliseconds) and accuracy (proportion correct). For each task a single performance measure has been selected on the basis that it comes from a normal data distribution, has no floor or ceiling effects, does not have restricted range and has good reliability, stability and sensitivity to change (Fredrickson et al. 2010; Hammers et al. 2011). The tasks from the CBB are described in their order of administration below.
The Detection (DET) task is a simple reaction time test shown to measure psychomotor function. In this task, the participant must attend to the card in the center of the screen and respond to the question “has the card turned over?” Participants were instructed to press the “Yes” button as soon as the card turns face up. The face of the card is always the same generic joker card. The task ends after 35 correct trials have been recorded. Trials on which anticipatory responses occurred were excluded and another trial was given so that all participants completed the 35 trials. The primary performance measure for this task was reaction time in milliseconds (speed), which was normalized using a logarithmic base 10 (log10) transformation.
The Identification (IDN) task is a choice reaction time test shown to measure visual attention. In this task, the participant must attend to the card in the center of the screen, and respond to the question “Is the card red?” Participants were required to press the “Yes” button if it is and the “No” button it is not. The face of the cards displayed were either red or black joker cards in equivalent numbers in random order. These cards were different to the generic joker card used in the DET task. The task ends after 30 correct trials. Trials on which anticipatory responses occurred were excluded and another trial was given so that all participants completed the 30 trials. The primary performance measure for this task was reaction time in milliseconds (speed), which was normalized using a log10 transformation.
The One Card Learning (OCL) task is a continuous visual recognition learning task that assesses visual learning within a pattern separation model (Yassa et al. 2010). Theoretical models of pattern separation model specify that information is organized in orthogonal and distinct non-overlapping representations so that that new memories can be stored rapidly without interference (Norman & O'Reilly 2003). In this task the participant must attend to the card in the center of the screen and respond to the question “have you seen this card before in this task?” If the answer was yes, participants were instructed to press the “Yes” button, and the “No” button if the answer was no. Normal playing cards were displayed (without joker cards). In this task, six cards are drawn at random from the deck and are repeated throughout the task. These four cards are interspersed with distractors (non-repeating cards). The task ends after 80 trials, without rescheduling for post-anticipatory correct trials. The primary performance measure for this task was the proportion of correct answers (accuracy), which was normalized using an arcsine square-root transformation.
The One-Back (OBK) task is a task of working memory and attention. Similar in presentation to the OCL task, participants must attend to the card in the center of the screen and respond to the question “is this card the same as that on the immediately previous trial?” If the answer was yes, participants were instructed to press the “Yes” button, and the “No” button if the answer was no. The task ends after 30 correct trials. A correct but post-anticipatory response led to scheduling of an extra trial. The primary performance measure for this task was the proportion of correct answers (accuracy), which was normalized using an arcsine square-root transformation.
For each participant, each performance measure from the four tasks in the CBB was computed as reported previously (Lim et al. 2012a). For each performance measure, the mean and standard deviation (SD) was computed for the HA group according to their age in deciles (e.g., 51–60, 61–70, 71–80, 81–90). These means and SDs were then used to standardize scores on each of the four cognitive tasks for each participant. A learning/working memory composite score was computed by averaging the standardized scores for the OCL and OBK tasks, and an attention/psychomotor function composite score was computed by averaging the standardized scores for the DET and IDN tasks. For each individual, both composite scores were then re-standardized using the mean and SD for each composite score computed from the HC group and then transformed once more so that each had a mean of 100 and a standard deviation of 10. This was achieved by first multiplying each standardized score by 10 and then adding 100. If data for one or both of the tasks that contributed to each composite was missing, the composite score was not computed. There was no missing data for the attention/psychomotor function composite and 26 (HA = 17 cases, AD = 9 cases) missing data for the learning/working memory composite score.
To evaluate the first hypothesis that the composite scores would be sensitive to AD-related cognitive impairment, we conducted two analysis of covariance (ANCOVA), with age, premorbid IQ, and level of depressive symptoms entered as covariates. For each composite score, Hedge’s g was used to quantify the magnitude of impairment in each of the clinical groups relative to the healthy controls. We also determined the extent to which performance on each composite was worse in the AD group than in the MCI using ANCOVA with age, premorbid IQ, and level of depressive symptoms entered as covariates. Once again for each comparison Hedge’s g was used to quantify the magnitude of impairment in the AD group relative to the MCI group. Receiver operating characteristic (ROC) curves were then generated to illustrate the relationship between clinical sensitivity and specificity of each composite for classification of MCI and AD groups, as measured by the area under the curve (AUC) statistic. AUC values were compared to those obtained for the MMSE in the same analyses with statistical significance indicated when 95% confidence intervals for each estimate did not overlap. For classification of cognitive impairment in MCI and AD, the value of each composite score that provided the optimal balance between sensitivity and specificity was identified from the ROC curve using Youden’s J statistic (Swets 1996). The predictive power of the combination of the optimum cut-score for each composite in predicting MCI and AD was then determined by computing the odds ratios for the classification of cognitive impairment in each clinical group (versus the HC group). Finally the relationship between the cognitive composite scores and disease severity was determined by collapsing data for the MCI and AD group and classifying each individual according to their score on the CDR Sum of Boxes score. Curve fitting analysis was then used to determine the extent to which scores on each of the cognitive composites was associated with increased CDR Sum of Boxes scores.
To evaluate our second hypothesis that the cognitive composite scores would show high test-retest reliability and stability, we computed mean change scores and test-retest reliability statistics over four months for the two CogState composite scores. This was conducted in a subgroup of AIBL participants who had consented to serial computerized cognitive assessments (Lim et al. 2013b). Average measure intraclass correlation coefficients (ICC) were used to compute the test-retest reliability of the two composites, in both the total group and in each clinical classification group separately.
Cognitive function in healthy controls
In the HA group, the attention/psychomotor composite was not associated significantly with premorbid IQ (r = 0.07, p >0.05) or level of education. It was associated significantly with levels of depressive (r = 0.11, p < 0.05) and anxiety symptoms (r = 0.10, p < 0.05). The learning/working memory composite was not associated significantly with premorbid IQ (r = -0.06, p > 0.05), or levels of depressive (r = 0.02, p > 0.05), or anxiety symptoms (r = 0.01, p > 0.05).
Magnitude of cognitive impairment in MCI and AD
As has been reported previously (Lim et al. 2012a), comparison of the demographic variables between clinical groups indicated significant differences in age, premorbid IQ, and level of depressive symptoms (see Table 1). As such, these variables were included as covariates in comparisons of the CBB composite measures between groups.
Results of the ANCOVAs revealed statistically significant group differences for the learning/working memory composite, F(2,769) = 305.56, p < 0.001, and the attention/psychomotor function composite, F(2,794) = 26.52, p < 0.001. Post-hoc comparisons indicated that adults with MCI and AD performed significantly worse than HC on the learning/working memory composite, and the magnitudes of these differences were, by convention, large (MCI g = 2.15, 95% CI = 1.91, 2.38; AD g = 3.18, 95% CI = 2.91, 3.28). The AD group also performed significantly worse than the MCI group on the learning/working memory score with this difference moderate in magnitude (g = 0.84 95% CI = 0.49, 1.18; p < 0.01). Adults with MCI and AD also performed significantly worse than HA on the attention/psychomotor composite, although these differences were moderate-to-large in magnitude (MCI g = 0.51, 95% CI = 0.30, 0.72; AD g = 1.03, 95% CI = 0.73, 1.33). The AD group also performed significantly worse than the MCI group on the attention/psychomotor function score with the differences moderate in magnitude (is g = 0.40 95% CI = 0.07, 0.74).
Sensitivity and specificity of CBB composite scores in assessing cognitive impairment in MCI and AD
Areas under ROC curves for MCI and AD groups relative to healthy controls
Sensitivity (95% CI) score < 90
Specificity (95% CI) score < 90
Area under ROC curve (95% CIs)
52.9% (38.5%, 67.1%)
85.7% (82.8%, 88.3%)
0.73 (0.64, 0.82)
41.1% (31.7%, 51.1%)
85.7% (82.8%, 88.3%)
0.67 (0.61, 0.73)
Score < 90
Score < 90
100.0% (91.5%, 100.0%)
84.7% (81.7%, 87.4%)
0.99 (0.98, 1.00)
80.4% (71.6%, 87.4%)
84.7% (81.7%, 87.4%)
0.91 (0.87, 0.94)
Prediction of MCI and AD from combined composite scores
Odds ratio, with impaired memory defined as scores of < 90
Normal memory normal attentional function (N)
Impaired memory normal attentional function (N)
Odds ratio (accuracy impaired)
Healthy controls (HC)
Mild cognitive impairment (MCI)
HC vs. MCI
26.19 (13.45, 50.98)
Alzheimer’s disease (AD)
HC vs. AD
30.00 (10.05, 89.60)
Relationship to disease severity
For the relationship between MMSE scores and the attention/psychomotor composite, trend analysis indicated no statistically significant relationships in any clinical group. The relationship between MMSE scores and the learning/working memory composite was best described by a linear function in both the MCI (r = 0.38) and AD (r = 0.12) groups, although this relationship was statistically significant only for the MCI group.
Test-retest reliability and group mean (standard deviation) of each clinical group over a four month assessment period
ICC (95% CI)
0.90 (0.87, 0.92)
0.95 (0.93, 0.96)
0.94 (0.92, 0.96)
0.78 (0.70, 0.85)
0.94 (0.90, 0.97)
0.86 (0.78, 0.92)
0.77 (0.58, 0.89)
0.91 (0.84, 0.96)
Results of this study supported our first hypothesis that the learning/working memory composite and the attention/psychomotor composite, derived from the outcome measures on the CBB, would be sensitive to detecting cognitive impairment in MCI and AD. In AD, we observed a large impairment for both cognitive composite scores, although the magnitude of impairment on the learning/working memory composite was much greater than that for the attention/psychomotor composite. Neuropsychological models of the cognitive tasks that contribute to the learning/working memory composite suggest that normal performance on these tasks is likely to depend on the integrity of the hippocampus and temporal lobe (i.e. pattern separation, e.g., Yassa et al. 2010) and prefrontal cortex and anterior cingulate (i.e. working memory, Andrewes 2001; Lezak 1995). Normal performance on the tasks that contribute to attentional functions are likely to depend on integrity of subcortical brain regions including the basal ganglia as well as cortical regions such as the prefrontal and parietal cortices (Andrewes 2001; Lezak 1995). The presence of a relatively greater impairment in cognitive functions dependent on cortical and limbic brain regions (i.e., learning and working memory) with relatively subtle impairment in motor and attentional functions is consistent with neuropsychological models of AD which emphasise that cognitive impairment characteristic of both prodromal and clinically classified AD is disruption to memory and executive function (Baddeley et al. 1991; Kensinger et al. 2003; McKhann et al. 2011). This pattern of impairment is also consistent with the predilection of AD-related neuronal loss in the medial temporal lobe and other cortical brain areas (Jack et al. 2009; Villemagne et al. 2013).
Differences in the nature of impairment for the two cognitive composite scores were also evident in their sensitivity to detecting AD-related cognitive impairment in individuals. The learning/working memory composite was most sensitive to AD-related cognitive impairment with 100% of AD cases classified as impaired when the criterion for abnormality was set at a score of 90. When the criterion for abnormality was decreased to 80, the sensitivity for abnormality decreased to only 86% (Figure 1). As expected, the attention/psychomotor composite showed lower levels of sensitivity, with only 53% of AD cases identified when sensitivity was set at the least conservative level (i.e., score of 90). Taken together, these data indicate that with the use of these composite scores, cognitive impairment in AD will present as a relatively large impairment in working memory and learning and with relatively intact psychomotor and attentional functions. The nature and magnitude of this cognitive impairment is consistent with the descriptions of AD cases from the neuropsychological literature (Andrewes 2001; McKhann et al. 2011). While it is unsurprising that patients with clinical defined AD showed poor performance on a measure of learning and working memory, the high specificity of the learning/working memory composite, with the lesser impairment on the attention/psychomotor composite also indicates that the CogState tests themselves can be used effectively in patients with AD and suggests further that this pattern of performance may even be useful to clinicians investigating the aetiology of cognitive impairment in older adults.
As expected, in adults with MCI, cognitive impairment was qualitatively similar but quantitatively less pronounced to that observed for clinically diagnosed AD. Compared to healthy adults, the MCI group showed large impairment on the learning/working memory composite (g = 2.2), although not as great as that observed for the same composite in AD. While performance on the attention/psychomotor composite was also impaired compared to healthy adults, the magnitude of this impairment was only moderate (g = 0.51). Once again this impairment was less than that observed for the same composite in AD. Despite these impairment, performance on both the attention/psychomotor function and learning working memory composites in the MCI group was superior to that in the AD group. When considered for individuals, a score of ≤90 on the learning/working memory composite had optimal sensitivity and specificity for detecting cognitive impairment in MCI. At the optimum cut score for the attention/psychomotor composite, the sensitivity was only 40%, with a specificity of 85%. Therefore, as was observed for AD, cognitive impairment in MCI was characterised best as a large abnormality in working memory and learning with relatively normal psychomotor and attentional function. The likelihood that a combination of abnormal performance on the learning/working memory composite with normal performance on the attention/psychomotor composite could predict MCI or AD was very high, since individuals who met this criteria were 26 times more likely to have MCI or 30 times more likely to have AD than those who did not meet the criteria.
For the relationship between cognition and disease severity in the MCI and AD groups, while a significant linear relationship was observed between disease severity and the attention/psychomotor composite, this relationship was driven mainly by individuals with the most extreme scores on the severity measure. Furthermore the magnitude of this relationship was only small. In contrast to these more reflexive aspects of cognition, disease severity was strongly associated with the learning/working memory composite.
The second hypothesis that the attention/psychomotor composite and the learning/working memory composite would show high test-retest reliability and stability in healthy adults, adults with MCI and AD, was also supported. Assessments on the same tests conducted four times in three months showed that both composite scores remained stable and showed test-retest reliability with repeated administration. Thus, despite repeated testing over relatively short retest intervals, including in patients with cognitive impairment, both composites showed no evidence of practice effects, and estimates of within subject variability remained low. Further, estimates of test-retest reliability for each composite were, by convention, high (r > 0.70). These results are consistent with findings from earlier clinical studies of MCI and AD groups, which have shown that performance on the individual tests from the CBB show little to no practice effects, have high test-retest reliability, and have low within-subject variability (Darby et al. 2012; Fredrickson et al. 2010; Lim et al. 2013b). While individual measures from the CogState battery have been shown to be sensitive to cognitive decline in MCI (e.g. Lim et al. 2012a, b), it will be important now to determine the extent to which composite scores derived in this study will be also sensitive to cognitive decline in MCI.
Taken together, results of this study converge to suggest that the performance on the learning/working memory and attention/psychomotor composites of the CBB can be used to identify reliably cognitive impairment in people with, and at risk of AD. Thus the two composite scores from the CBB should be useful in screening for cognitive impairment in MCI or AD. The estimates of sensitivity for the composite scores from the CBB reported here are equivalent or slightly better than those reported previously for other screening instruments used commonly in the early identification of aMCI and AD. For example, estimates of the sensitivity for the MoCA show that the total score has a high sensitivity to AD, while retaining a high specificity. However, as was observed in the current study, the sensitivity of the MoCA to aMCI is also relatively high (81%; (Freitas et al. 2013)), provided that estimates of lower levels of specificity (e.g. 77%) are tolerated. As with the MoCA, performance on the MMSE also shows relatively high sensitivity and specificity for identifying cognitive impairment in AD (Freitas et al. 2013; Strauss et al. 2006) although its sensitivity to cognitive impairment in MCI is lower than the MoCA and that reported here, even if a low specificity is allowed. The equivalence of these estimates occurs mainly because all studies use the same method, where the test instrument is applied to identify cognitive impairment in a group of individuals that has been carefully assessed and undergone relatively rigorous inclusion and exclusion criteria. One strength of the composite scores, observed in this study, was that they were not associated with estimates of premorbid intelligence or depressive symptoms. The psychomotor attention composite was associated with levels of anxiety symptoms although the magnitude of this association was very small. Taken together this analysis of associations suggests that the composite cognitive scores may be useful in settings where issues such as low premorbid intelligence or mood obscure the assessment of cognitive function in individuals undergoing clinical workup for MCI or AD.
When cognitive assessments are conducted in unselected populations, such as in epidemiological studies, neuropsychological tests are always preferred to bedside screening instruments for the identification of cognitive impairment (Clarke et al. 2000; Ellis et al. 2009; Petersen et al. 2010). This is because neuropsychological tests provide more reliable estimates of individual cognitive functions. Acceptable estimates of validity and reliability are found for bedside screening instruments only when their total score is used, and accordingly, scores of their subscales have been shown to have limited use for describing the nature of cognitive impairment in individuals (Strauss et al. 2006). A limitation of bedside screening instruments for tracking cognitive function is reflected in their absence as outcome measures in clinical trials of drugs designed to improve cognitive function in MCI or AD. This is due to restriction in the range of possible scores for people with dementia; the presence of ceiling effects in data distributions; and the substantial practice effects that occur with repeated administrations. As with other neuropsychological tests, the tasks from the CBB have been used extensively in epidemiological studies, as well as in clinical trials (Bateman et al. 2011; Ellis et al. 2009). Furthermore associations between performance on the CBB tasks and that on conventional neuropsychological measures indicate that each task has sound construct validity (Maruff et al. 2009). The data shown here extend these findings to suggest that the two cognitive composite scores that arise from individual measures that comprise the CBB could be applied effectively as a cognitive screening instrument not only for assessing cognitive impairment in dementia, but also in other neurological and psychiatric conditions.
There are some limitations in the current study that warrant consideration in interpreting the results. First, as has been considered already the current data for this study were drawn from studies of MCI and AD, therefore the high sensitivity and specificity demonstrated here should be challenged in individuals from a clinical setting. Second, while the MCI group recruited here met clinical criteria shown to increase the risk of AD (Petersen et al. 1999), amyloid biomarkers (e.g., Petersen et al. 2010) were not measured in the current analysis. Therefore, although the current data show that the learning/working memory composite score was sensitive to the cognitive impairment that characterizes MCI more study is needed to determine the relationship the relationship between the CogState composite scores and amyloid biomarkers within this clinical classification. These issues notwithstanding the current results do show that the composite scores from the CogState Brief Battery have good potential for use in screening for cognitive impairment related to MCI and AD.
- Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Phelps CH: The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging and Alzheimer’s Association workgroup. Alzheimer’s & Dementia. 2011, 7 (3): 270-279. 10.1016/j.jalz.2011.03.008.View ArticleGoogle Scholar
- Andrewes D: Neuropsychology: From theory to practice. 2001, East Sussex: Psychology PressGoogle Scholar
- Baddeley AD, Bressi S, Della Sala S, Logie R, Spinnler H: The decline of working memory in Alzheimer’s disease: a longitudinal study. Brain. 1991, 114 (6): 2521-2542. 10.1093/brain/114.6.2521.View ArticlePubMedGoogle Scholar
- Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Xiong C: Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimer's Research & Therapy. 2011, 3 (1): 1-13.View ArticleGoogle Scholar
- Clarke PJ, Marshall VW, Ryff CD, Rosenthal CJ: Well-being in Canadian seniors: findings from the Canadian Study of Health and Aging. Canadian Journal on Aging. 2000, 19: 139-159. 10.1017/S0714980800013982.View ArticleGoogle Scholar
- Collie A, Maruff P, Darby DG, McStephen M: The effects of practice on the cognitive test performance of neurologically normal individuals assessed at brief test-retest intervals. Journal of the International Neuropsychological Society. 2003, 9: 419-428.View ArticlePubMedGoogle Scholar
- Darby D, Fredrickson J, Fredrickson A, Moore L, Sach J, Woodward M: Community screening for early signs of dementia. Alzheimer’s & Dementia. 2009, 5 (5): 3-4.View ArticleGoogle Scholar
- Darby D, Maruff P, Collie A, McStephen M: Mild cognitive impairment can be detected by multiple assessments in a single day. Neurology. 2002, 59 (7): 1042-1046. 10.1212/WNL.59.7.1042.View ArticlePubMedGoogle Scholar
- Darby D, Pietrzak RH, Fredrickson J, Woodward M, Moore L, Fredrickson A, Maruff P: Intra-individual cognitive decline using a brief computerized cognitive screening test. Alzheimer’s & Dementia. 2012, 8: 95-104. 10.1016/j.jalz.2010.12.009.View ArticleGoogle Scholar
- Davison SL, Bell RJ, Gavrilescu M, Searle K, Maruff P, Gogos A, Davis SR: Testosterone improves verbal learning and memory in postmenopausal women: results from a pilot study. Maturitas. 2011, 70: 307-311. 10.1016/j.maturitas.2011.08.006.View ArticlePubMedGoogle Scholar
- Ellis KA, Bush AI, Darby D, De Fazio D, Foster J, Hudson P, Group, T. A. R: The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: Methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer’s disease. International Psychogeriatrics. 2009, 21 (4): 672-687. 10.1017/S1041610209009405.View ArticlePubMedGoogle Scholar
- Falleti MG, Maruff P, Collie A, Darby DG: Practice effects associated with the repeated assessment of cognitive function using the CogState battery at 10-minute, one week, and one month test-retest intervals. Journal of Clinical and Experimental Neuropsychology. 2006, 28 (7): 1096-1112.View ArticleGoogle Scholar
- Folstein MF, Folstein SE, McHugh PR: “Mini-mental state”: a practical method for grading cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975, 12: 189-198. 10.1016/0022-3956(75)90026-6.View ArticlePubMedGoogle Scholar
- Fredrickson J, Maruff P, Woodward M, Moore L, Fredrickson A, Sach J, Darby D: Evaluation of the usability of a brief computerized cognitive screening test in older people for epidemiological studies. Neuroepidemiology. 2010, 34: 65-75. 10.1159/000264823.View ArticlePubMedGoogle Scholar
- Freitas S, Simões MR, Alves L, Santana I: Montreal cognitive assessment: validation study for mild cognitive impairment and Alzheimer disease. Alzheimer Disease & Associated Disorders. 2013, 27 (1): 37-43. 10.1097/WAD.0b013e3182420bfe.View ArticleGoogle Scholar
- Hammers D, Spurgeon E, Ryan K, Persad C, Barbas N, Heidebrink J, Giordani B: Validity of a brief computerized cognitive screening test in dementia. Journal of Geriatric Psychiatry and Neurology. 2012, 25 (2): 89-99. 10.1177/0891988712447894.View ArticlePubMedGoogle Scholar
- Hammers D, Spurgeon E, Ryan K, Persad C, Heidebrink J, Barbas N, Giordani B: Reliability of repeated cognitive assessment of dementia using a brief computerized battery. American Journal of Alzheimer's Disease & Other Dementias. 2011, 26 (4): 326-333. 10.1177/1533317511411907.View ArticleGoogle Scholar
- Jack CR, Lowe VJ, Weigand SD, Wiste HJ, Senjem ML, Knopman DS, Initiative, T. A. s. D. N: Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer’s disease: implications for sequence of pathological events in Alzheimer’s disease. Brain. 2009, 132: 1355-1365. 10.1093/brain/awp062.View ArticlePubMedPubMed CentralGoogle Scholar
- Jaeger J, Hårdemark HG, Zettergren A, Sjögren N, Hannesdottir K: Paper presented at the Alzheimer’s Association International Conference, Paris, France. Does repeated daily testing improve measurement sensitivity to the cognitive effects of donepezil in mild-to-moderate Alzheimer’s Disease?. 2011Google Scholar
- Kensinger EA, Shearer DK, Locascio JJ, Growdon JH, Corkin S: Working memory in Alzheimer’s disease and early Parkinson’s disease. Neuropsychology. 2003, 17 (2): 230-239.View ArticlePubMedGoogle Scholar
- Lezak MD: Neuropsychological Assessment. 1995, New York: Oxford University Press, 3Google Scholar
- Lim YY, Ellis KA, Ames D, Darby D, Harrington K, Martins RN, AIBL Research Group: Aβ amyloid, cognition and APOE genotype in the preclinical stages of Alzheimer’s disease. Alzheimer’s & Dementia. 2013, 9 (5): 538-45. 10.1016/j.jalz.2012.07.004.View ArticleGoogle Scholar
- Lim YY, Ellis KA, Harrington K, Ames D, Martins RN, Masters CL, AIBL RG: Use of the CogState Brief Battery in the assessment of Alzheimer’s disease related cognitive impairment in the Australian Imaging, Biomarker and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology. 2012, 34 (4): 345-358. 10.1080/13803395.2011.643227.View ArticlePubMedGoogle Scholar
- Lim YY, Ellis KA, Harrington K, Pietrzak RH, Gale J, Ames D, AIBL RG: Cognitive decline in adults with mild cognitive impairment and high Aβ amyloid: prodromal Alzheimer’s disease?. Journal of Alzheimer's Disease. 2013, 33 (4): 1167-1176.PubMedGoogle Scholar
- Lim YY, Ellis KA, Pietrzak RH, Ames D, Darby D, Harrington K, AIBL RG: Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology. 2012, 79: 1645-1652. 10.1212/WNL.0b013e31826e9ae6.View ArticlePubMedGoogle Scholar
- Lim YY, Jaeger J, Harrington K, Ashwood T, Ellis KA, Stöffler A, Maruff P: Three-month stability of the CogState Brief Battery in healthy older adults, mild cognitive impairment, and Alzheimer’s disease: results from the Australian Imaging, Biomarkers, and Lifestyle-Rate of Change Substudy (AIBL-ROCS). Archives of Clinical Neuropsychology. 2013, 28 (4): 320-30. 10.1093/arclin/act021.View ArticlePubMedGoogle Scholar
- Lim YY, Pietrzak RH, Ellis KA, Jaeger J, Harrington K, Ashwood T, Maruff P: Rapid decline in episodic memory in healthy older adults with high amyloid-β. Journal of Alzheimer's Disease. 2013, 33 (3): 675-679. doi:10.3233/JAD-2012-121516PubMedGoogle Scholar
- Maruff P, Collie A, Darby D, Weaver-Cargin J, Masters C, Currie J: Subtle memory decline over 12 months in mild cognitive impairment. Dement Geriatr Cognitve and Geriatric Disorders. 2004, 18 (3–4): 342-348.View ArticleGoogle Scholar
- Maruff P, Thomas E, Cysique L, Brew B, Collie A, Snyder P, Pietrzak RH: Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. Archives of Clinical Neuropsychology. 2009, 24 (2): 165-178. 10.1093/arclin/acp010.View ArticlePubMedGoogle Scholar
- McKhann GM, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA wok group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology. 1984, 34: 939-944. 10.1212/WNL.34.7.939.View ArticlePubMedGoogle Scholar
- McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CRJ, Kawas CH, Phelps CH: The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute of Aging and the Alzheimer’s Association workgroup. Alzheimer's & Dementia. 2011, 7 (3): 263-269. 10.1016/j.jalz.2011.03.005.View ArticleGoogle Scholar
- Miller DS, Hurt SW, Dewerth-Pallmeyer A, Samuelson P, van der Putten D, Jones L, Butler A: Paper presented at the International Society for CNS Clinical Trials and Methodology, Toronto, Canada. Ratings surveillance to identify rater errors. 2008Google Scholar
- Miller DS, Young A, Estergard W, Henley D, Sundell K: Paper presented at the 4th Clinical Trials in Alzheimer’s Disease Conference, San Diego, USA. Variability in MMSE scores between screening and baseline visits in 2 large, multi-national Alzheimer’s Disease study programs: a concern and potential solution. 2011Google Scholar
- Morris JC: The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1983, 43: 2412-2414.View ArticleGoogle Scholar
- Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H: The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatric Society. 2005, 53 (4): 695-699. 10.1111/j.1532-5415.2005.53221.x.View ArticleGoogle Scholar
- Nathan PJ, Boardley R, Scott N, Berges A, Maruff P, Sivananthan T, Lai R: The safety, tolerability, pharmacokinetics and cognitive effects of GSK239512, a selective histamine H3 receptor antagonist in patients with mild to moderate Alzheimer’s disease: a preliminary investigation. Current Alzheimer Research. 2013, 10 (240–251): 240-View ArticlePubMedGoogle Scholar
- Norman KA, O’Reilly RC: Modeling hippocampal and neocortical contributions to recognition memory: a complementary-learning-systems approach. Psychological review. 2003, 110 (4): 611-646.View ArticlePubMedGoogle Scholar
- Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, Marder SR: The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. American Journal of Psychiatry. 2008, 165 (2): 203-213. 10.1176/appi.ajp.2007.07010042.View ArticlePubMedGoogle Scholar
- Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, Weiner MW: Alzheimer’s Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology. 2010, 74: 201-209. 10.1212/WNL.0b013e3181cb3e25.View ArticlePubMedPubMed CentralGoogle Scholar
- Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology. 1999, 56 (3): 303-308. 10.1001/archneur.56.3.303.View ArticlePubMedGoogle Scholar
- Proust-Lima C, Amieva H, Dartigues JF, Jacqmin-Gadda H: Sensitivity of four psychometric tests to measure cognitive changes in brain aging-population-based studies. American Journal of Epidemiology. 2007, 165 (3): 344-350.View ArticlePubMedGoogle Scholar
- Rowe CC, Ellis KA, Rimajova M, Bourgeat P, Pike KE, Jones G, Villemagne V: Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of Aging. 2010, 31: 1275-1283. 10.1016/j.neurobiolaging.2010.04.007.View ArticlePubMedGoogle Scholar
- Snaith RP, Zigmond AS: The hospital anxiety and depression scale. British Medical Journal. 1986, 292: 344-View ArticlePubMedPubMed CentralGoogle Scholar
- Snyder PJ: The retooling of old cognitive tests as an interim step on the path to validating a next generation of neuropsychological paradigms and assays. Alzheimer’s & Dementia. 2013, 9: S1-S3. 10.1016/j.jalz.2012.12.005.View ArticleGoogle Scholar
- Strauss E, Sherman EMS, Spreen O: A compendium of neuropsychological tests: Administration, norms and commentary. 2006, New York: Oxford University Press, 3Google Scholar
- Swets JA: Signal detection theory and ROC analysis in psychology and diagnostics: Collected papers. 1996, New Jersey: Lawrence Erlbaum AssociatesGoogle Scholar
- Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O, AIBL Research Group: Amyloid β deposition, neurodegeneration and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study. Lancet Neurology. 2013, 12 (4): 357-367. 10.1016/S1474-4422(13)70044-9.View ArticlePubMedGoogle Scholar
- Wechsler D: Wechsler Test of Adult Reading: Examiner’s manual. 2001, San Antonio, TX: The Psychological CorporationGoogle Scholar
- Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Petersen RC: Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on mild cognitive impairment. Journal of Internal Medicine. 2004, 256 (3): 240-246. 10.1111/j.1365-2796.2004.01380.x.View ArticlePubMedGoogle Scholar
- Yassa MA, Stark SM, Bakker A, Albert MS, Gallagher M, Stark CE: High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment. Neuro Image. 2010, 51 (3): 1242-1252.PubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/2050-7283/1/30/prepub
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