Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer’s disease

Table 2 Areas under ROC curves for MCI and AD groups relative to healthy controls

Composite	Clinical group	Sensitivity (95% CI) score < 90	Specificity (95% CI) score < 90	Area under ROC curve (95% CIs)	Standard error	p
Psychomotor/attention	AD	52.9% (38.5%, 67.1%)	85.7% (82.8%, 88.3%)	0.73 (0.64, 0.82)	0.05	< 0.0001
	MCI	41.1% (31.7%, 51.1%)	85.7% (82.8%, 88.3%)	0.67 (0.61, 0.73)	0.03	< 0.0001
		Score < 90	Score < 90
Learning/working memory	AD	100.0% (91.5%, 100.0%)	84.7% (81.7%, 87.4%)	0.99 (0.98, 1.00)	0.01	< 0.0001
	MCI	80.4% (71.6%, 87.4%)	84.7% (81.7%, 87.4%)	0.91 (0.87, 0.94)	0.02	< 0.0001

Note: ROC = receiver operating characteristic; MCI = mild cognitive impairment; AD = Alzheimer’s disease; Attention/psychomotor composite = average of the standardized Detection and Identification scores; Learning/working memory composite = average of the standardized One Card Learning and One Back scores; MMSE = Mini Mental State Examination.

ISSN: 2050-7283