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Table 1 General characteristics of studies that were performed by CBT (N = 19)

From: Interventions promoting mental health dimensions in infertile women: a systematic review

Authors, year [Reference]

Type of intervention

Intervention protocol

Outcome

Results

Conclusion

Quality assessment EPHPP

Neisi et al., 2012 [23]

Cognitive-behavioral-religious

8 sessions training with homework

Mental health

F = 7.18, Eta = 0.52, P = 0.001

Cognitive-behavioral religious group intervention was effective in increasing mental health (P < 0.001).

Moderate

Gharaei. V et al., 2003 [4]

Cognitive behavioral training

Individual and face-to-face training for 15–20 days

Anxiety

State anxiety Pre, while, post Mean(SD) = 48.6(13.5), 35.6(10.6), 39.8(9.5), pre-while studying p = 0.002, pre-post p = 0.001

Trait anxiety Pre, while, post Mean(SD) = 47.0(10.1), 38.6(8.4), 41.7(7.9), pre-while studying p = 0.000, pre-post p = 0.000, while, post studying p = 0.006

Cognitive behavioral training was effective in reducing anxiety.

Moderate

Oraki et al., 2015 [24]

Cognitive behavioral intervention for anger management

10 sessions of 90 min

Mental health

Pre, post Mean(SD) = 46.84(4.71), 33.53(4.91), F = 29.57, P = 0.001

Training of anger control upon cognitive- behavioral approach caused to increase the mental health in the experimental group.

Moderate

Ashrafian et al., 2019 [25]

Integrative Positive Cognitive Behavioral Therapy

10 sessions of 90 min

Infertility stress and hope

Infertility stress pre, post Mean(SD) = 140.13(2.100), 127.27(4.41), F, p = 77.21, 0.001

Hope pre, post Mean(SD) = 27.47(5.139), 32.20 (5.14), F, p = 77.21, 0.006

Intervention was effective in reducing infertility stress and increasing the hope of infertile women (P < 0.001).

Strong

Kraaij et al., 2015 [26]

cognitive behavioral Self-Help Program (CBS)

4 days a week ,1 h per day for a period of 4 weeks

Depression

Baseline-first posttest F, Eta = 15.53, 0.28, P = 0.00

Baseline-second posttest F, Eta = 9.32, 0.20, P = 0.00

CBS was effective in improving the depression score and its positive effect remained in the follow-up period.

Strong

Manochehri et al.,2005 [27]

Cognitive-emotional-behavioral group counseling

10 sessions of 1.5 h

Mental health

Mental health pre, post, fallow up 1, 2 Mean(SD) = 130.85(59.35), 63.7(28.68), 56.85(17.62), 62.14(23.02), F = 14.43,P = 0.01

The intervention was effective in improving mental health and its effect continued until 3 months after the intervention.

Moderate

Mosalanejad et al., 2012 [18]

Cognitive behavioral therapy

1 h and 30 min weekly session’s group therapy in 15 week

Stress, anxiety, depression, hardiness

Depression pre, post, Mean(SD) = 13.11(4.76), 6.41(3.26), P = 0.001

Anxiety pre, post, Mean(SD) = 11.11(4.45), 7.17(3.84), P = 0.007

stress, pre, post, Mean(SD) = 14.64(4.07), 6.7(4.22), P = 0.001

Significant differences was in level of stress (p = 0.000), anxiety (p = 0.001) and depression (0.007) in treatment group pretest with posttest.

Moderate

Faramarzi et al., 2013 [28]

Cognitive Behavioral Therapy (CBT) and

Pharmacotherapy

CBT group (gradual relaxation training, restructuring, and eliminating of negative automatic thoughts and dysfunctional attitudes to infertility for 10 sessions) Antidepressant therapy (20 mg fluoxetine daily for 90 days)

Infertility Stress

CBT Infertility Stress pre, post Mean(SD) = 3.5 (0.62), 2.7 (0.62) p < 0.05

fluoxetine Infertility Stress pre, post Mean(SD) = 3.5 (0.53),0.3.2 ( 4.4) p < 0.05

Both methods significantly reduced the Infertility Stress but CBT was superior to fluoxetine in resolving and reducing of infertility stress.

Strong

Faramarzi et al., 2008 [29]

Psychological intervention, psychotropic medication

CBT groups (10 sessions on relaxation training, restructuring, and eliminating negative automatic thoughts and dysfunctional attitudes to infertility ), antidepressant therapy (20 mg fluoxetine daily for 90 days)

Mental health, Depression

Fluoxetine mental health pre, post, Mean(SD) = 26.7 (11.9), 18.2 (8.8), P = 0.002

CBT pre, post, Mean(SD) = 28.5 (10.3) 13.6 (7.1), P < 0.001

fluoxetine Depression pre, post, Mean(SD)= 23.2 (8.6), 14.3 ( 8.5) ,p < 0.001

CBT Depression pre, post, Mean(SD) = 20( 7.9), 7.7 ( 4.8), p < 0.001

Both methods significantly reduced the mental health and Depression scores, the decrease in the CBT group was significantly greater than the fluoxetine group.

Moderate

Faramarzi et al., 2008 [30]

Cognitive behavioral therapy and fluoxetine

CBT group (gradual relaxation training, restructuring, and eliminating of negative automatic thoughts and dysfunctional attitudes to infertility for 10 sessions), Antidepressant therapy (20 mg fluoxetine daily for 90 days)

Depression, anxiety

Fluoxetine depression pre, post, Mean(SD) = 23.2(8.6), 14.3(8.5), P < 0.001

CBT depression pre, post, Mean(SD) = 20.1(7.9), 7.7(4.8), p < 0.001

Both methods significantly reduced depression and anxiety CBT was superior to fluoxetine in the resolution or reducing

of depression and anxiety.

Moderate

Ahmadali Noorbala, 2008 [31]

Psychiatric interventions(cognitive-behavioral therapy, supportive psychotherapy, fluoxetine)

Group 1 (6-month psychological treatment with cognitive-behavioral therapy (CBT), supportive psychotherapy, and 20 to 60 mg per day of fluoxetine

Depression

Depression Pre, post Mean(SD) = 18.7(9.7) to 10.7(5.8), P < 0.001

Depression was significantly lower in group 1 than in group 2 (P < 0.001).

Moderate

Ahmadali Noorbala, 2008 [32]

Pharmacotherapy and psychotherapy

Treated with fluoxetine based on severity of disease, 6–8 session cognitive-behavioral therapy and supportive psychotherapy for six months)

Depression

Depression Pre, post Mean(SD) = 18.7 (9.7), 10.7 (5.8), p < 0.0001

Psychiatric interventions (pharmacotherapy and psychotherapy) was effective in reduction of depression symptoms (p < 0.0001).

Moderate

Heydari. P et al., 2002 [33]

Cognitive behavioral therapy

CBT for 12–13 days

Anxiety

State anxiety Pre, post Mean(SD) = 46.4(9.9), 31.6(8.1), P = 0.0001

Trait anxiety Pre, post Mean(SD) = 47.1(11.1), 40.6(9.9), P = 0.001

Cognitive-behavioral therapy was effective in reducing anxiety.

Moderate

Talaei. A et al., 2014 [34]

Cognitive behavioral group therapy

10 Sessions of 120 min for 2/5 months

Depression

Beck depression Pre, post Mean(SD) = 20(7.37), 14.5(6.54), P < 0.05

Hamilton depression Pre, post Mean(SD) = 21.9(7.23), 16.0(10.83), P < 0.05, F = 35.37

Cognitive behavioral Group therapy was effective in improving depression (p < 0.001).

Moderate

Starabadi et al.,2020 [35]

Cognitive- Behavioral Therapy

10 sessions of 90 min

Infertility Stress and Depression

Infertility Stress Pre, post Mean(SD) = 50.43(16.10), 134.70(14.92), F = 38.22, P = 0.0001

Depression Pre, post Mean(SD) = 29.66(6.12), 21.30(4.56), F = 67.27, P = 0.0001

CBT was effective in decrease of infertility stress and depression.

Strong

Mosalanejad et al., 2012 [36]

E-Cognitive Group Therapy with Emotional Disclosure

Weekly 12-hour meeting for three months), painting sessions (art therapy) and written and verbal emotional disclosure ,individually and in group

Depression,

Anxiety, Stress

Depression Pre, post Mean(SD) = 14 (2.38), 8 (2.62), F, P = 000, 0.99

Anxiety Pre, post Mean (SD) = 13.96 (2.59), 8. 06 (2.63), F, P = 2. 9 4, 0.09

Stress Pre, post Mean (SD) = 13.93 (3.15), 8. 84 (2.65), F, P = 10.32, 002

Psychological intervention

lowered the level of Depression, Anxiety, Stress; the mean difference between two groups was significant (p = 0.001).

Moderate

van Dongen et al., 2016 [37]

E-Therapy

CBT and usual care and digital psycho-education

Depression,

anxiety

Risk difference (95%CI) = 24% (2–46%), P = 0.03

E-Therapy was effective to reduction in the percentage women having clinically relevant symptoms of anxiety, depression in intervention group compared with the control group 3 months after the first ART cycle.

Moderate

Minden B et al., 2010 [38]

Web-based treatment

web-based approach to providing a cognitive behavioral intervention (modules Included cognitive restructuring, relaxation, and behavioral activation to commonly endorsed symptoms and experiences of infertile individuals)

General and infertility-related psychological stress

General stress pre, post Mean(SD) = 5.0(1.3), 5.1(1.1)

F(intervention condition and time) = 6.045, p = 0.02

Online cognitive behavioral approach was effective to reduced general stress.

Moderate

Haemmerli et al., 2010 [39]

Internet-based support

8-week (13 sessions) Internet-based cognitive-behavioral treatment

Mental health, pregnancy rate

CES-D pre, post, Mean(SD) = 16.7 (11.7), 11.8 (8.1), D (Between group) = 0.337

State anxiety pre, post, Mean(SD) = 41.4 (11), 36.7 (9.3), D (Between group) = 0.383

Trait anxiety pre, post, Mean(SD) = 41.7 (9.8), 37.8 (9.5), D (Between group) = 0.338

IDS pre, post, Mean(SD) = 25.2 (3.9), 21.6 (5.3), D (Between group) = 0.163

The intervention significantly reduced the depression level of clinically distressed and depressed participants but no effects on pregnancy rate.

Moderate

  1. EPHPPa: Effective Public Health Practice Project, d = Cohen’s d effect size, D: Difference between the Pre- and Post-measures, MD: mean difference, CES-D center for epidemiologic studies depression scale, IDS infertility distress scale