Efficacy of exposure and response prevention therapy in mixed reality for patients with obsessive-compulsive disorder: study protocol for a randomized controlled trial

Table 1 Standard protocol items: recommendation for interventional trials (SPIRIT) timeline

		Study Period
	Enrolment	Allocation	Intervention period	Assessments
TIMEPOINT**	-t ₀	0	6 weeks	t ₀	t ₁	t ₂
ENROLLMENT:
*Eligibility screen*	X
*Informed consent*				X
*Primary measures*				X	X	X
*Secondary measures*				X	X	X
*Allocation*		X
INTERVENTIONS:	MERP or self-guided exposure therapy
*Intervention*			X
*Self-guided exposure therapy*			X
ASSESSMENTS:
*Demographic interview*				X
*M.I.N.I.*				X
*Y-BOCS*				X	X	X
*Expectation of MERP*				X	X
*Subjective Appraisal*					X
*OCI-R*				X	X	X
*BDI-II*				X	X	X
*WHOQOL-BREF*				X	X	X
*GAD-7*				X	X	X
*TPI*					X
*BEAQ*				X	X	X
*State sensitive questionnaire*			X
*Further assessments during MERP (violation of expectancy and psychophysiological parameter)*			X
*SUD*			X

M.I.N.I. = Mini-International Neuropsychiatric Interview, Y-BOCS = Yale-Brown Obsessive Compulsive Scale, OCI-R = Obsessive Compulsive Inventory-Revised, BDI-II = Beck Depression Inventory, WHOQOL-BREF = World Health Organization Quality of Life-BREF (quality of life), GAD = Generalized Anxiety Scale 7, TPI = Temple Presence Inventory, BEAQ = Brief Experiential Avoidance Questionnaire, SUD = Subjective Units of Distress

ISSN: 2050-7283