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Table 2 Effects of SGA on mean cognitive stores stratified by COMT rs5993883 genotype

From: Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder

COMT rs5993883 GG (n = 58) GT (n = 128) TT (n = 52)
  No-SGA (STD) SGA (STD) beta p value r2 No-SGA (STD) SGA (STD) beta p value r2 No-SGA (STD) SGA (STD) beta p value r2
Rey Visual Memory Immediate recall 20.9 (6.9) 17.4 (7.2) −4.13 0.09 0.15 20.7 (6.7) 19.2 (6.4) −1.8 0.88 0.22 22.2 (6.9) 20.0 (5.5) −2.2 0.27 0.16
Rey Visual Memory Delayed recall 20.6 (6.9) 17.4 (7.4) −3.96 0.11 0.14 21.0 (6.2) 19.3 (7.4) −0.14 0.91 0.19 22.3 (6.8) 20.6 (6.1) −2.25 0.25 0.23
CVLT-IIa learning score 56.6 (10.1) 45.1 (11.7) 10.88 0.0006 0.51 52.0 (12.2) 49.3 (10.9) −1.77 0.46 0.17 55.2 (8.9) 50.1 (12.0) −2.77 0.32 0.36
CVLT-II short term delayed free recall 11.6 (3.2) 9.8 (4.5) −1.6 0.18 0.15 11.0 (3.4) 10.9 (3.5) −0.12 0.85 0.15 12.0 (3.4) 11.1 (3.8) −0.68 0.54 0.12
CVLT-II long-term delayed free recall 12.9 (3.1) 9.4 (3.2) −3.43 0.0026 0.28 11.4 (3.7) 10.7 (3.1) −0.22 0.75 0.18 12.7 (3.1) 11.0 (3.1) −0.92 0.29 0.19
WCSTb total errors 24.4 (23.5) 27.5 (19.1) 9.3 0.21 0.21 25.1 (22.9) 23.7 (22.9) −1.17 0.7 0.19 17.7 (15.9) 24.1 (24.2) 6.7 0.23 0.3
WCST perseverative responses 14.3 (15.4) 15.4 (14.6) 4.98 0.33 0.16 15.4 (16.3) 14.1 (16.4) −1.61 0.62 0.18 9.5 (9.2) 14.5 (17.3) 5.27 0.17 0.25
WCST number of categories 5.2 (1.7) 5.2 (1.3) −0.4 0.47 0.12 5.1 (1.7) 5.1 (1.9) 0.07 0.83 0.16 5.5 (1.4) 5.0 (1.9) −0.52 26 0.28
TMT Part A Time (sec) 30.5 (13.3) 34.2 (10.9) 3.73 0.39 0.15 29.6 (9.9) 30.5 (11.9) 0.042 0.98 0.15 28.4 (9.3) 30.5 (11.5) 1.3 0.62 0.4
TMT Part B Time (sec) 75.9 (36.5) 82.1 (30.6) 2.44 0.83 0.16 72.5 (27.4) 80.6 (36.4) 3.5 0.55 0.25 65.2 (25.6) 80.5 (36.5) 10.6 0.2 0.35
PGNGc response time (msec) 468.2 (47.2) 492.2 (61.6) 18.6 0.33 0.19 467.5 (53.4) 463.8 (59.5) −1.79 0.55 0.2 451.2 (46.8) 459.6 (43.5) 11.3 0.38 0.22
PGNG Target accuracy (%) 0.96 (0.05) 0.88 (0.11) 0.083 0.004 0.23 0.95 (0.07) 0.95 (0.06) 0.002 0.86 0.17 0.98 (0.05) 0.96 (0.07) −0.02 0.23 0.12
  1. This model was adjusted for age, education, gender, diagnosis, prior hospitalizations, benzodiazepines and antidepressant use
  2. a CVLT-II California verbal learning test-II
  3. b WCST Wisconsin card sorting test
  4. c PGNG parametric go-no-go test