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Table 4 Multivariable logistic regression on the association between having memory-related SCS and covariates (n=6,960)1;2

From: Memory-related subjective cognitive symptoms in the adult population: prevalence and associated factors – results of the LIFE-Adult-Study

Covariates3 df Wald’s χ² p value OR 95%-CI
Sex, women vs. men 1 2.686 0.101 0.92 0.83-1.03
Age, every additional year 1 0.705 0.401 1.00 0.99-1.00
Education, with university degree vs. without 1 1.901 0.168 1.10 0.96-1.26
SES
 Medium vs. low 1 0.115 0.735 1.02 0.90-1.17
 High vs. los 1 2.727 0.099 0.84 0.69-1.03
Physical comorbidity, yes vs. no
 Arterial hypertension 1 0.163 0.687 0.98 0.88-1.09
 Hyperlipidemia 1 0.443 0.506 0.96 0.87-1.07
 Thyroid disease 1 2.960 0.085 1.10 0.99-1.24
 Cardiac arrhythmia 1 1.044 0.307 1.09 0.93-1.28
 Diabetes mellitus 1 0.165 0.684 1.04 0.88-1.23
 Any cancer 1 0.576 0.448 0.94 0.80-1.11
 Coronary heart disease/angina pectoris 1 0.017 0.897 1.02 0.75-1.40
 Myocardial infarction 1 1.723 0.189 1.28 0.89-1.84
 Stroke 1 0.001 0.972 1.01 0.70-1.44
 Cardiac insufficiency 1 0.032 0.857 0.97 0.68-1.38
 Epilepsy 1 1.620 0.203 0.77 0.51-1.15
 Peripheral artery occlusive disease/intermittent claudication 1 0.495 0.482 0.84 0.51-1.37
 Parkinson’s disease 1 0.312 0.576 0.76 0.29-1.98
 Multiple sclerosis 1 0.311 0.577 0.79 0.35-1.81
Depressive symptomatology
 CES-D score, every additional point 1 0.054 0.816 1.00 0.99-1.01
Anxiety
 GAD-7 score, every additional point 1 0.446 0.504 1.01 0.99-1.03
Cognition3
 VFT, every additional stated animal 1 0.026 9.871 1.00 0.99.1.01
  1. 1missing data for n = 1,874 (21.2%) of the 8,834 participants; 2Nagelkerke’s R² of the model = 0.004; 3The cognitive test results of Trail Making Test (TMT) A, TMT B and TMT ratio score B/A could not be additionally included into this regression model (model I) because the cognitive test results were not independent from each other. As a result, three additional regressions models (II-IV) were calculated including TMT A result (model II), TMT B result (model III), and TMT ratio score B/A result (model IV) instead of VFT test result as cognitive covariate. In these models, the different TMT tests results were also not significantly associated with having memory-related SCS: Every additional second in TMT A yielded an OR = 1.00 (95%-CI = 0.99-1.00; Wald’s χ² = 0.486, df=1, p=0.486; model II), every additional second in TMT B yielded an OR = 1.00 (95%-CI = 1.00-1.00; Wald’s χ² = 0.100, df=1, p=0.752; model III), and higher TMT ratio score B/A an OR =1.00 (95%-CI = 0.95-1.05; Wald’s χ² = 0.010, df=1, p=0.922; model IV). The replacement of the VFT test score by the other cognitive test results in regression model II-IV did not change the (non-significant) association of the other covariates with having memory-related SCS
  2. CES-D Center of Epidemiologic Studies Depression Scale, CI confidence interval, GAD-7 Generalized Anxiety Disorder Screener, df degree of freedom, OR odds ratio, SES socio-economic status, SCS subjective cognitive symptoms VFT Verbal Fluency Test