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Table 3 Associations of creatinine-cystatin C-based eGFR and serum CRP level with depressive and apathy symptoms, and dispositional optimism in 2355 post-myocardial infarction patients

From: Kidney dysfunction, systemic inflammation and mental well-being in elderly post-myocardial infarction patients

  Depressive symptoms
Crude Model 1 Model 2 Model 3
Creatinine-cystatin C-based eGFR -0.181 -0.116 -0.084 -0.074
t = –8.904 t = -5.118 t = -3.691 t = -3.195
p <0.001 p <0.001 p <0.001 p = 0.001
C-reactive protein levels 0.106 0.082 0.051 0.035
t = 5.171 t = 4.017 t = 2.476 t = 1.650
p <0.001 p <0.001 p = 0.013 p = 0.099
  Apathy subscale
Crude Model 1 Model 2 Model 3
Creatinine-cystatin C-based eGFR -0.219 -0.135 -0.101 -0.084
t = -10.879 t = -6.002 t = -4.440 t = -3.598
p <0.001 p <0.001 p <0.001 p <0.001
C-reactive protein levels 0.137 0.110 0.083 0.065
t = 6.696 t = 5.479 t = 3.999 t = 3.039
p <0.001 p <0.001 p <0.001 p = 0.002
  Dispositional optimism
Crude Model 1 Model 2 Model 3
Creatinine-cystatin C-based eGFR 0.194 0.089 0.072 0.063
t = 9.613 t = 3.979 t = 3.152 t = 2.693
p <0.001 p <0.001 p = 0.002 p = 0.007
C-reactive protein levels -0.094 -0.065 -0.047 -0.033
t = -4.585 t = -3.244 t = -2.258 t = -1.556
p <0.001 p = 0.001 p = 0.024 p = 0.12
  1. Data are beta-coefficients (p-value) after linear regression analysis
  2. CRP values were naturally log transformed before analysis because of a positively skewed distribution
  3. Model 1: adjusted for age, sex, education, and 4 randomized groups (using 3 dummy variables)
  4. Model 2: additionally adjusted for body mass index, smoking status, alcohol use, antidepressant use, statin use, time since myocardial infarction, stroke, and diabetes
  5. Model 3: full model, additionally adjusted for the other possible predictors (Creatinine-cystatin C-based eGFR, or CRP levels)