Kidney dysfunction, systemic inflammation and mental well-being in elderly post-myocardial infarction patients

BMC Psychology

Table 3 Associations of creatinine-cystatin C-based eGFR and serum CRP level with depressive and apathy symptoms, and dispositional optimism in 2355 post-myocardial infarction patients

	Depressive symptoms
	Crude	Model 1	Model 2	Model 3
Creatinine-cystatin C-based eGFR	-0.181	-0.116	-0.084	-0.074
	t = –8.904	t = -5.118	t = -3.691	t = -3.195
	p <0.001	p <0.001	p <0.001	p = 0.001
C-reactive protein levels	0.106	0.082	0.051	0.035
	t = 5.171	t = 4.017	t = 2.476	t = 1.650
	p <0.001	p <0.001	p = 0.013	p = 0.099
	Apathy subscale
	Crude	Model 1	Model 2	Model 3
Creatinine-cystatin C-based eGFR	-0.219	-0.135	-0.101	-0.084
	t = -10.879	t = -6.002	t = -4.440	t = -3.598
	p <0.001	p <0.001	p <0.001	p <0.001
C-reactive protein levels	0.137	0.110	0.083	0.065
	t = 6.696	t = 5.479	t = 3.999	t = 3.039
	p <0.001	p <0.001	p <0.001	p = 0.002
	Dispositional optimism
	Crude	Model 1	Model 2	Model 3
Creatinine-cystatin C-based eGFR	0.194	0.089	0.072	0.063
	t = 9.613	t = 3.979	t = 3.152	t = 2.693
	p <0.001	p <0.001	p = 0.002	p = 0.007
C-reactive protein levels	-0.094	-0.065	-0.047	-0.033
	t = -4.585	t = -3.244	t = -2.258	t = -1.556
	p <0.001	p = 0.001	p = 0.024	p = 0.12

Data are beta-coefficients (p-value) after linear regression analysis
CRP values were naturally log transformed before analysis because of a positively skewed distribution
Model 1: adjusted for age, sex, education, and 4 randomized groups (using 3 dummy variables)
Model 2: additionally adjusted for body mass index, smoking status, alcohol use, antidepressant use, statin use, time since myocardial infarction, stroke, and diabetes
Model 3: full model, additionally adjusted for the other possible predictors (Creatinine-cystatin C-based eGFR, or CRP levels)

ISSN: 2050-7283