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Table 2 Categories of creatinine-cystatin C-based eGFR and serum level CRP in relation to depressive and apathy symptoms, and dispositional optimism in 2355 post-myocardial infarction patients

From: Kidney dysfunction, systemic inflammation and mental well-being in elderly post-myocardial infarction patients

Creatinine-cystatin C-based eGFR, ml/min/1.73 m2 ≥90
(n = 517)
60 – 89
(n = 1233)
30 – 59
(n = 552)
<30
(n = 53)
Test statistic P-value for trend
Depressive symptoms:
 Median (P25, P75) 1 (0 – 2) 1 (0 – 3) 2 (1 – 4) 2 (1 – 4)   
 crude 1.54 (SE 0.08)a 1.92 (SE 0.06)b 2.68 (SE 0.12)c 3.12 (SE 0.41)c F(1, 2351) = 80.6 <0.001
 model 1 1.72 (SE 0.10)a 1.94 (SE 0.06)a 2.47 (SE 0.10)b 2.90 (SE 0.31)b F(1, 2335) = 31.4 <0.001
 model 2 1.79 (SE 0.10)a 1.95 (SE 0.06)a 2.34 (SE 0.10)b 2.67 (SE 0.31)b F(1, 2280) = 17.4 <0.001
Apathy subscale:
 Median (P25, P75) 0 (0 – 1) 1 (0 – 2) 1 (0 – 2) 2 (1 – 2.5)   
 crude 0.74 (SE 0.04)a 0.97 (SE 0.03)b 1.29 (SE 0.04)c 1.64 (SE 0.14)d F(1, 2351) = 108.5 <0.001
 model 1 0.85 (SE 0.04)a 0.98 (SE 0.03)b 1.18 (SE 0.04)c 1.47 (SE 0.14)d F(1, 2335) = 36.1 <0.001
 model 2 0.87 (SE 0.04)a 0.99 (SE 0.03)b 1.12 (SE 0.04)c 1.38 (SE 0.13)c F(1, 2280) = 20.4 <0.001
Dispositional optimism:
 Median (P25, P75) 7 (6 – 8) 7 (6 – 8) 6 (5 – 7) 6 (4 – 7)   
 crude 6.71 (SE 0.06)a 6.38 (SE 0.04)b 5.82 (SE 0.08)c 5.59 (SE 0.25)c F(1, 2351) = 94.7 <0.001
 model 1 6.49 (SE 0.07)a 6.36 (SE 0.04)a 6.04 (SE 0.07)b 5.91 (SE 0.22)b F(1, 2335) = 21.6 <0.001
 model 2 6.46 (SE 0.07) 6.35 (SE 0.04) 6.08 (SE 0.07) 6.01 (SE 0.22) F(1, 2280) = 14.2 <0.001
C-reactive protein levels, mg/L <1
(n = 766)
1 – 3
(n = 798)
3 – 5
(n = 330)
≥5
(n = 461)
  P-value for trend
Depressive symptoms:
 Median (P25, P75) 1 (0 – 3) 1 (0 – 3) 1 (0 – 3) 2 (1 – 3.7)   
 crude 1.86 (SE 0.08)a 1.87 (SE 0.07)a 2.15 (SE 0.13)a 2.55 (SE 0.12)b F(1, 2351) = 28,34 <0.001
 model 1 1.92 (SE 0.08)a 1.88 (SE 0.08)a 2.12 (SE 0.12)a 2.45 (SE 0.11)b F (1, 2351) = 17.0 <0.001
 model 2 1.97 (SE 0.08) 1.89 (SE 0.08) 2.07 (SE 0.12) 2.30 (SE 0.10) F(1, 2280) = 6.7 0.010
Apathy subscale:
 Median (P25, P75) 1 (0 – 1,1) 1 (0 – 2) 1 (0 – 2) 1 (0 – 2)   
 crude 0.88 (SE 0.03)a 0.98 (SE 0.04)b 1.05 (SE 0.05)b 1.26 (SE 0.05)c F(1, 2351) = 42.8 <0.001
 Model 1 0.90 (SE 0.04)a 0.99 (SE 0.03)a 1.04 (SE 0.05)a 1.21 (SE 0.05)b F (1, 2335) = 27.6 <0.001
 model 2 0.93 (SE 0.04)a 0.99 (SE 0.03)a 1.01 (SE 0.05)a 1.16 (SE 0.05)b F (1, 2280) = 14.4 <0.001
Dispositional optimism:
 Median (P25, P75) 7 (6 – 8) 7 (6 – 8) 6 (5 – 8) 6 (5 – 7)   
 crude 6.46 (SE 0.06)a 6.39 (SE 0.06)a 6.16 (SE 0.10)b 6.02 (SE 0.08)b F(1, 2351) = 24.9 <0.001
 model 1 6.40 (SE 0.06) 6.38 (SE 0.06) 6.17 (SE 0.09) 6.10 (SE 0.07) F (1, 2335) = 12.8 <0.001
 model 2 6.37 (SE 0.06) 6.38 (SE 0.06) 6.18 (SE 0.09) 6.16 (SE 0.07) F (1, 2280) = 6.8 0.009
  1. Data are reported as (adjusted) mean and standard errors (SE)
  2. Analysis of covariance (ANCOVA) was used to determine significance for linear trend over the 4 categories of eGFR and CRP levels
  3. Model 1: adjusted for age, sex, education, and 4 randomized groups (using 3 dummy variables)
  4. Model 2: additionally adjusted for body mass index, smoking status, alcohol use, antidepressant use, statin use, time since myocardial infarction, stroke and diabetes
  5. abcd Superscript letters that are dissimilar indicate significant differences in post-hoc tests