Creatinine-cystatin C-based eGFR, ml/min/1.73 m2 | ≥90 (n = 517) | 60 – 89 (n = 1233) | 30 – 59 (n = 552) | <30 (n = 53) | Test statistic | P-value for trend |
Depressive symptoms: | ||||||
 Median (P25, P75) | 1 (0 – 2) | 1 (0 – 3) | 2 (1 – 4) | 2 (1 – 4) |  |  |
 crude | 1.54 (SE 0.08)a | 1.92 (SE 0.06)b | 2.68 (SE 0.12)c | 3.12 (SE 0.41)c | F(1, 2351) = 80.6 | <0.001 |
 model 1 | 1.72 (SE 0.10)a | 1.94 (SE 0.06)a | 2.47 (SE 0.10)b | 2.90 (SE 0.31)b | F(1, 2335) = 31.4 | <0.001 |
 model 2 | 1.79 (SE 0.10)a | 1.95 (SE 0.06)a | 2.34 (SE 0.10)b | 2.67 (SE 0.31)b | F(1, 2280) = 17.4 | <0.001 |
Apathy subscale: | ||||||
 Median (P25, P75) | 0 (0 – 1) | 1 (0 – 2) | 1 (0 – 2) | 2 (1 – 2.5) |  |  |
 crude | 0.74 (SE 0.04)a | 0.97 (SE 0.03)b | 1.29 (SE 0.04)c | 1.64 (SE 0.14)d | F(1, 2351) = 108.5 | <0.001 |
 model 1 | 0.85 (SE 0.04)a | 0.98 (SE 0.03)b | 1.18 (SE 0.04)c | 1.47 (SE 0.14)d | F(1, 2335) = 36.1 | <0.001 |
 model 2 | 0.87 (SE 0.04)a | 0.99 (SE 0.03)b | 1.12 (SE 0.04)c | 1.38 (SE 0.13)c | F(1, 2280) = 20.4 | <0.001 |
Dispositional optimism: | ||||||
 Median (P25, P75) | 7 (6 – 8) | 7 (6 – 8) | 6 (5 – 7) | 6 (4 – 7) |  |  |
 crude | 6.71 (SE 0.06)a | 6.38 (SE 0.04)b | 5.82 (SE 0.08)c | 5.59 (SE 0.25)c | F(1, 2351) = 94.7 | <0.001 |
 model 1 | 6.49 (SE 0.07)a | 6.36 (SE 0.04)a | 6.04 (SE 0.07)b | 5.91 (SE 0.22)b | F(1, 2335) = 21.6 | <0.001 |
 model 2 | 6.46 (SE 0.07) | 6.35 (SE 0.04) | 6.08 (SE 0.07) | 6.01 (SE 0.22) | F(1, 2280) = 14.2 | <0.001 |
C-reactive protein levels, mg/L | <1 (n = 766) | 1 – 3 (n = 798) | 3 – 5 (n = 330) | ≥5 (n = 461) |  | P-value for trend |
Depressive symptoms: | ||||||
 Median (P25, P75) | 1 (0 – 3) | 1 (0 – 3) | 1 (0 – 3) | 2 (1 – 3.7) |  |  |
 crude | 1.86 (SE 0.08)a | 1.87 (SE 0.07)a | 2.15 (SE 0.13)a | 2.55 (SE 0.12)b | F(1, 2351) = 28,34 | <0.001 |
 model 1 | 1.92 (SE 0.08)a | 1.88 (SE 0.08)a | 2.12 (SE 0.12)a | 2.45 (SE 0.11)b | F (1, 2351) = 17.0 | <0.001 |
 model 2 | 1.97 (SE 0.08) | 1.89 (SE 0.08) | 2.07 (SE 0.12) | 2.30 (SE 0.10) | F(1, 2280) = 6.7 | 0.010 |
Apathy subscale: | ||||||
 Median (P25, P75) | 1 (0 – 1,1) | 1 (0 – 2) | 1 (0 – 2) | 1 (0 – 2) |  |  |
 crude | 0.88 (SE 0.03)a | 0.98 (SE 0.04)b | 1.05 (SE 0.05)b | 1.26 (SE 0.05)c | F(1, 2351) = 42.8 | <0.001 |
 Model 1 | 0.90 (SE 0.04)a | 0.99 (SE 0.03)a | 1.04 (SE 0.05)a | 1.21 (SE 0.05)b | F (1, 2335) = 27.6 | <0.001 |
 model 2 | 0.93 (SE 0.04)a | 0.99 (SE 0.03)a | 1.01 (SE 0.05)a | 1.16 (SE 0.05)b | F (1, 2280) = 14.4 | <0.001 |
Dispositional optimism: | ||||||
 Median (P25, P75) | 7 (6 – 8) | 7 (6 – 8) | 6 (5 – 8) | 6 (5 – 7) |  |  |
 crude | 6.46 (SE 0.06)a | 6.39 (SE 0.06)a | 6.16 (SE 0.10)b | 6.02 (SE 0.08)b | F(1, 2351) = 24.9 | <0.001 |
 model 1 | 6.40 (SE 0.06) | 6.38 (SE 0.06) | 6.17 (SE 0.09) | 6.10 (SE 0.07) | F (1, 2335) = 12.8 | <0.001 |
 model 2 | 6.37 (SE 0.06) | 6.38 (SE 0.06) | 6.18 (SE 0.09) | 6.16 (SE 0.07) | F (1, 2280) = 6.8 | 0.009 |