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Table 1 Studies included in the P-curve analysis, taken from Karg et al. (2011) [10]

From: Triangulating meta-analyses: the example of the serotonin transporter gene, stressful life events and major depression

Original study

Quoted text from original paper

Design

Key result

Karg et al. 2011 [10]

Potential studies were identified from previous meta-analyses and review articles and through PubMed at the National Library of Medicine, using the search terms depression or depressed and “serotonin transporter” or 5-HTTLPR and stress or maltreatment. We subsequently checked the reference sections of the identified publications and contacted authors through e-mail to identify additional studies in press or review. We considered all English-language studies published by November 2009 assessing whether 5-HTTLPR moderates the relationship between stress and depression. Two studies were excluded because their data were part of another larger study included in the analysis. In total, data from 54 publications met inclusion criteria and were included in the analysis.

Meta-analysis

Z-statistic from one-tailed P-value

Study

N

Type of stressor

P-value (one-tailed)

Z-statistic

Aguilera

534

Childhood maltreatment

0.0001

3.719

Kilpatrick

589

**Hurricane exposure + low social support

0.0015

2.968

Brummett

288

**Alzheimer caregiving

0.0015

2.968

Sen

268

**Medical internship

0.002

2.878

Lazary

567

Stressful life events

0.0025

2.807

Dick

956

Stressful life events

0.004

2.652

Kim

521

Specific medical condition

0.005

2.576

Benjet

78

Childhood maltreatment

0.005

2.576

Lenze

23

Specific medical condition

0.0068

2.468

Kendler

549

Stressful life events

0.007

2.457

Nakatani

2509

Specific medical condition

0.0075

2.432

Aslund

1482

Childhood maltreatment

0.0078

2.418

Caspi

845

Childhood maltreatment/stressful life events

0.01

2.326

Mandelli

670

Stressful life events

0.0112

2.284

Kumsta

125

Childhood maltreatment

0.0117

2.267

Mossner

72

Specific medical condition

0.0125

2.241

Ramasubbu

51

Specific medical condition

0.013

2.226

Cervilla

737

Stressful life events

0.0143

2.189

Bull

98

Specific medical condition

0.015

2.170

Jacobs

374

Stressful life events

0.02

2.054

Goldman

984

Stressful life events

0.0203

2.048

Kohen

150

Specific medical condition

0.0225

2.005

Kaufman

196

Childhood maltreatment

0.0225

2.005

Lotrich

71

Specific medical condition

0.025*

1.960

Taylor

110

Stressful life events

0.0268*

1.930

Otte

557

Specific medical condition

0.0275*

1.919

Bukh

290

Stressful life events

0.035*

1.812

Kim

732

Stressful life events

0.0385*

1.768

  1. *Two-tailed P-value ≥0.05 and therefore excluded from P-curve analysis
  2. **Not included in stratified analysis
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BMC Psychology

ISSN: 2050-7283

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