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Table 1 Studies included in the P-curve analysis, taken from Karg et al. (2011) [10]

From: Triangulating meta-analyses: the example of the serotonin transporter gene, stressful life events and major depression

Original study Quoted text from original paper Design Key result
Karg et al. 2011 [10] Potential studies were identified from previous meta-analyses and review articles and through PubMed at the National Library of Medicine, using the search terms depression or depressed and “serotonin transporter” or 5-HTTLPR and stress or maltreatment. We subsequently checked the reference sections of the identified publications and contacted authors through e-mail to identify additional studies in press or review. We considered all English-language studies published by November 2009 assessing whether 5-HTTLPR moderates the relationship between stress and depression. Two studies were excluded because their data were part of another larger study included in the analysis. In total, data from 54 publications met inclusion criteria and were included in the analysis. Meta-analysis Z-statistic from one-tailed P-value
Study N Type of stressor P-value (one-tailed) Z-statistic
Aguilera 534 Childhood maltreatment 0.0001 3.719
Kilpatrick 589 **Hurricane exposure + low social support 0.0015 2.968
Brummett 288 **Alzheimer caregiving 0.0015 2.968
Sen 268 **Medical internship 0.002 2.878
Lazary 567 Stressful life events 0.0025 2.807
Dick 956 Stressful life events 0.004 2.652
Kim 521 Specific medical condition 0.005 2.576
Benjet 78 Childhood maltreatment 0.005 2.576
Lenze 23 Specific medical condition 0.0068 2.468
Kendler 549 Stressful life events 0.007 2.457
Nakatani 2509 Specific medical condition 0.0075 2.432
Aslund 1482 Childhood maltreatment 0.0078 2.418
Caspi 845 Childhood maltreatment/stressful life events 0.01 2.326
Mandelli 670 Stressful life events 0.0112 2.284
Kumsta 125 Childhood maltreatment 0.0117 2.267
Mossner 72 Specific medical condition 0.0125 2.241
Ramasubbu 51 Specific medical condition 0.013 2.226
Cervilla 737 Stressful life events 0.0143 2.189
Bull 98 Specific medical condition 0.015 2.170
Jacobs 374 Stressful life events 0.02 2.054
Goldman 984 Stressful life events 0.0203 2.048
Kohen 150 Specific medical condition 0.0225 2.005
Kaufman 196 Childhood maltreatment 0.0225 2.005
Lotrich 71 Specific medical condition 0.025* 1.960
Taylor 110 Stressful life events 0.0268* 1.930
Otte 557 Specific medical condition 0.0275* 1.919
Bukh 290 Stressful life events 0.035* 1.812
Kim 732 Stressful life events 0.0385* 1.768
  1. *Two-tailed P-value ≥0.05 and therefore excluded from P-curve analysis
  2. **Not included in stratified analysis