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Table 3 Interaction between SGA and COMT polymorphism rs5993883 on cognition in bipolar patients (using GG genotype as a reference)

From: Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder

Cognitive parameter Verbal attentiona (r 2 = 0.25) Verbal delayed recalla (r 2 = 0.21) Cognitive controlb (r 2 = 0.15)
  beta p value beta p value beta p value
SGA −10.03 0.0019 −3.03 0.0022 −0.08 <0.0001
COMT genotype −4.65 0.013 −1.43 0.013 −0.007 0.54
Main Interaction 7.95 0.028 2.38 0.026 0.083 0.0005
  1. This model was adjusted for age, education, gender, diagnosis, prior hospitalizations, benzodiazepines and antidepressant use
  2. aAge, education and gender were also significant parameters in this model
  3. bAge was also a significant parameter in this model