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Table 1 Demographic characteristics

From: Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder

 

NO-SGAa

SGAa

p value

N (%) or

N (%) or

Mean (SD)

Mean (SD)

Gender

   

 Female

119 (69.2)

41(55.4)

0.037

 Male

53 (30.8)

33 (44.6)

 

Years of education in years (SD)

15.4 (2.9)

15.2 (3.2)

0.63

Age in years (SD)

40.3 (12.9)

40 (11.3)

0.83

Time since diagnosis in years (SD)

14.3 (11.7)

13.9 (10.7)

0.75

Previous hospitalizations

113 (65.7)

58 (78.4)

0.047

Medications

 Benzodiazepines

28 (16.3)

26 (35.1)

0.001

 Antidepressants

48 (27.9)

37 (50.0)

0.0008

 Chlorpromazine equivalents

NA

210 (787)

 

Mood symptoms

 HAMDb

8.9 (6.6)

8.2 (6)

0.43

 YMRSc

3.1 (4.1)

3.2 (3.8)

0.85

Diagnosis

 Bipolar I

115 (66.9)

63 (85.1)

0.014

 Bipolar II with recurrent depression

34 (19.7)

5 (6.8)

 

 Bipolar NOSd

18 (10.5)

3 (4.0)

 

 Schizoaffective, Bipolar

5 (2.9)

3 (4.0)

 

COMT rs5993883

 GG

44 (25.6)

14 (18.9)

0.5

 GT

88 (51.2)

40 (54.1)

 

 TT

40 (23.2)

20 (27.0)

 

Neuropsychological Tests (SD)

 Rey Visual Memory Immediate Recall

21.1 (6.8)

19.1 (6.3)

0.02

 Rey Visual Memory Delayed Recall

21.2 (6.5)

19.3 (7.03)

0.043

 CVLT-IIe Trials 1–5 Score (Learning)

53.9 (11.1)

48.7 (11.4)

0.0009

 CVLT-II Short Delay Recall Score

11.4 (3.4)

10.7 (3.7)

0.18

 CVLT-II Long Delay Recall Score

12.1 (3.5)

10.5 (3.7)

0.0008

 WCST-f Total Errors

23.2 (21.7)

24.5 (22.3)

0.67

 WCST- Perseverative Responses (Percentile)

50 (28.9)

49.9 (31)

0.95

 WCST-Categories

5.2 (1.7)

5.1 (1.8)

0.53

 TMTg A Time (seconds)

29.6 (10.7)

31.2 (11.6)

0.28

 TMT B Time (seconds)

71.5 (29.7)

80.8 (34.9)

0.03

 PGNGh Response Time (Level 1)

463.5 (50.8)

467.9 (56.5)

0.5

 PGNG Target Accuracy (Level 1)

0.9 (0.1)

0.9 (0.1)

0.10

  1. a SGA atypical antipsychotic, b HAMD the Hamilton rating scale for depression; c YMRS Young mania rating scale, d NOS not otherwise specified, e CVLT-II California verbal learning test-II, f WCST Wisconsin card sorting test, g TMT trail making test, h PGNG parametric go-no-go test