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Table 1 Demographic characteristics

From: Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder

  NO-SGAa SGAa p value
N (%) or N (%) or
Mean (SD) Mean (SD)
Gender    
 Female 119 (69.2) 41(55.4) 0.037
 Male 53 (30.8) 33 (44.6)  
Years of education in years (SD) 15.4 (2.9) 15.2 (3.2) 0.63
Age in years (SD) 40.3 (12.9) 40 (11.3) 0.83
Time since diagnosis in years (SD) 14.3 (11.7) 13.9 (10.7) 0.75
Previous hospitalizations 113 (65.7) 58 (78.4) 0.047
Medications
 Benzodiazepines 28 (16.3) 26 (35.1) 0.001
 Antidepressants 48 (27.9) 37 (50.0) 0.0008
 Chlorpromazine equivalents NA 210 (787)  
Mood symptoms
 HAMDb 8.9 (6.6) 8.2 (6) 0.43
 YMRSc 3.1 (4.1) 3.2 (3.8) 0.85
Diagnosis
 Bipolar I 115 (66.9) 63 (85.1) 0.014
 Bipolar II with recurrent depression 34 (19.7) 5 (6.8)  
 Bipolar NOSd 18 (10.5) 3 (4.0)  
 Schizoaffective, Bipolar 5 (2.9) 3 (4.0)  
COMT rs5993883
 GG 44 (25.6) 14 (18.9) 0.5
 GT 88 (51.2) 40 (54.1)  
 TT 40 (23.2) 20 (27.0)  
Neuropsychological Tests (SD)
 Rey Visual Memory Immediate Recall 21.1 (6.8) 19.1 (6.3) 0.02
 Rey Visual Memory Delayed Recall 21.2 (6.5) 19.3 (7.03) 0.043
 CVLT-IIe Trials 1–5 Score (Learning) 53.9 (11.1) 48.7 (11.4) 0.0009
 CVLT-II Short Delay Recall Score 11.4 (3.4) 10.7 (3.7) 0.18
 CVLT-II Long Delay Recall Score 12.1 (3.5) 10.5 (3.7) 0.0008
 WCST-f Total Errors 23.2 (21.7) 24.5 (22.3) 0.67
 WCST- Perseverative Responses (Percentile) 50 (28.9) 49.9 (31) 0.95
 WCST-Categories 5.2 (1.7) 5.1 (1.8) 0.53
 TMTg A Time (seconds) 29.6 (10.7) 31.2 (11.6) 0.28
 TMT B Time (seconds) 71.5 (29.7) 80.8 (34.9) 0.03
 PGNGh Response Time (Level 1) 463.5 (50.8) 467.9 (56.5) 0.5
 PGNG Target Accuracy (Level 1) 0.9 (0.1) 0.9 (0.1) 0.10
  1. a SGA atypical antipsychotic, b HAMD the Hamilton rating scale for depression; c YMRS Young mania rating scale, d NOS not otherwise specified, e CVLT-II California verbal learning test-II, f WCST Wisconsin card sorting test, g TMT trail making test, h PGNG parametric go-no-go test