George et al. ([1997])
|
42
|
92%
|
some
|
+ 8%
|
N/A
|
+
|
Tab one
|
HAMD21
|
26 ± 3 (5)
|
30 ± 4 (7)
|
30 ± 8 (5)
|
23 ± 9 (7)
|
-4 ± 7 (5)
|
7 ± 8 (7)
|
Avery et al. ([1999])
|
44
|
83%
|
+
|
+ 17%
|
-
|
+
|
Tab one
|
HAMD21
|
20 ± 8 (2)
|
21 ± 7 (4)
|
15 ± 2 (2)
|
11 ± 4 (4)
|
5 ± 7 (2)
|
10 ± 6 (4)
|
BDI21
|
20 ± 7 (2)
|
28 ± 7 (4)
|
14 ± 11 (2)
|
20 ± 11 (4)
|
6 ± 10 (2)
|
8 ± 10 (4)
|
Kimbrell et al. ([1999])
|
42
|
54%
|
N/A
|
+ 31%
|
N/A
|
-
|
All (Tab one)
|
HAMD21
|
24 ± 7 (3)
|
30 ± 8 (10)
|
25 ± 10 (3)
|
27 ± 10 (10)
|
-1 ± 9 (3)
|
3 ± 9 (10)
|
20Hz
|
24 ± 7 (3)
|
25 ± 7 (5)
|
25 ± 10 (3)
|
28 ± 8 (5)
|
-1 ± 9 (3)
|
-3 ± 8 (5)
|
1Hz
|
24 ± 7 (3)
|
34 ± 8 (5)
|
25 ± 10 (3)
|
27 ± 13 (5)
|
-1 ± 9 (3)
|
7 ± 11 (5)
|
Klein et al. ([1999])
|
59
|
76%
|
-
|
+ 19%
|
+ 23%
|
+
|
Tab two
|
HAMD17
|
25 ± 6 (32)
|
26 ± 6 (35)
|
20 ± 10 (32)
|
14 ± 9 (35)
|
5 ± 9 (32)
|
12 ± 8 (35)
|
MADRS
|
34 ± 8 (32)
|
34 ± 5 (35)
|
27 ± 12 (32)
|
20 ± 12 (35)
|
7 ± 11 (32)
|
14 ± 10 (35)
|
Loo et al. ([1999])
|
48
|
50%
|
some
|
+ 17%
|
+ 6%
|
+
|
Authors
|
HAMD21
|
25 ± 6 (9)
|
21 ± 7 (9)
|
19 ± 7 (9)
|
17 ± 7 (9)
|
6 ± 7 (9)
|
4 ± 7 (9)
|
MADRS
|
38 ± 6 (9)
|
33 ± 9 (9)
|
29 ± 10 (9)
|
26 ± 9 (9)
|
9 ± 9 (9)
|
7 ± 9 (9)
|
Padberg et al. ([1999])
|
51
|
61%
|
+
|
-
|
N/A
|
+
|
All
|
HAMD21
|
22 ± 9 (6)
|
28 ± 9 (12)
|
24 ± 10 (6)
|
25 ± 8 (12)
|
-2 ± 10 (6)
|
3 ± 8 (12)
|
Text 10Hz
|
22 ± 9 (6)
|
30 ± 10 (6)
|
24 ± 10 (6)
|
28 ± 9 (6)
|
-2 ± 10 (6)
|
2 ± 10 (6)
|
Fig one 0.3Hz
|
22 ± 9 (6)
|
27 ± 9 (6)
|
24 ± 10 (6)
|
22 ± 6 (6)
|
-2 ± 10 (6)
|
5 ± 8 (6)
|
Berman et al. ([2000])
|
42
|
30%
|
some
|
+ 5%
|
+ 5%
|
-
|
Tab one
|
HAMD25
|
37 ± 8 (10)
|
37 ± 10 (10)
|
36 ± 9 (10)
|
25 ± 9 (10)
|
1 ± 8 (10)
|
12 ± 10 (10)
|
Eschweiler et al. ([2000])
|
57
|
67%
|
N/A
|
-
|
+ 8%
|
+
|
Tab one
|
HAMD21
|
20 ± 4 (5)
|
27 ± 4 (7)
|
23 ± 6 (5)
|
22 ± 5 (7)
|
-3 ± 5 (5)
|
5 ± 5 (7)
|
BDI21
|
28 ± 10 (5)
|
40 ± 6 (7)
|
32 ± 9 (5)
|
33 ± 11 (7)
|
-4 ± 10 (5)
|
7 ± 10 (7)
|
George et al. ([2000])
|
44
|
63%
|
N/A
|
+ 30%
|
-
|
-
|
All (Tab one)
|
HAMD21
|
24 ± 4 (10)
|
28 ± 6 (20)
|
19 ± 6 (10)
|
18 ± 9 (20)
|
5 ± 5 (10)
|
10 ± 8 (20)
|
Garcia-Toro et al. ([2001a])
|
51
|
43%
|
+
|
-
|
N/A
|
+
|
Tab two
|
HAMD21
|
26 ± 5 (18)
|
27 ± 7 (17)
|
24 ± 4 (18)
|
20 ± 6 (17)
|
2 ± 5 (18)
|
7 ± 7 (17)
|
BDI17
|
26 ± 6 (18)
|
27 ± 9 (17)
|
24 ± 5 (18)
|
22 ± 7 (17)
|
2 ± 6 (18)
|
5 ± 8 (17)
|
Garcia-Toro et al. ([2001b])
|
44
|
55%
|
-
|
N/A
|
N/A
|
+D1
|
Tab one
|
HAMD21
|
27 ± 6 (11)
|
26 ± 6 (11)
|
18 ± 9 (11)
|
16 ± 8 (11)
|
9 ± 8 (11)
|
10 ± 7 (11)
|
BDI17
|
23 ± 7 (11)
|
27 ± 8 (11)
|
21 ± 8 (11)
|
19 ± 7 (11)
|
2 ± 8 (11)
|
8 ± 8 (11)
|
Manes et al. ([2001])
|
61
|
50%
|
some
|
N/A
|
N/A
|
-
|
Tab two
|
HAMD21
|
23 ± 7 (10)
|
23 ± 5 (10)
|
16 ± 8 (10)
|
14 ± 5 (10)
|
7 ± 8 (10)
|
9 ± 5 (10)
|
Boutros et al. ([2002])
|
51
|
22%
|
+
|
-
|
N/A
|
+
|
Tab two
|
HAMD25
|
36 ± 4 (7)
|
40 ± 10 (11)
|
26 ± 13 (7)
|
27 ± 13 (11)
|
10 ± 12 (7)
|
13 ± 12 (11)
|
Padberg et al. ([2002])
|
57
|
70%
|
+
|
N/A
|
N/A
|
+
|
All (Tab one, Fig two)
|
HAMD21
|
24 ± 6 (10)
|
24 ± 6 (10)
|
22 ± 6 (10)
|
17 ± 9 (10)
|
2 ± 6 (10)
|
7 ± 8 (10)
|
MADRS
|
30 ± 6 (10)
|
29 ± 6 (10)
|
29 ± 6 (10)
|
19 ± 9 (10)
|
1 ± 6 (10)
|
10 ± 8 (10)
|
Fitzgerald et al. ([2003])
|
46
|
43%
|
+
|
+ 10%
|
N/A
|
+
|
All
|
MADRS
|
36 ± 8 (20)
|
37 ± 8 (40)
|
35 ± 8 (20)
|
32 ± 8 (40)
|
1 ± 8 (20)
|
5 ± 8 (40)
|
BDI21
|
32 ± 9 (20)
|
34 ± 11 (40)
|
29 ± 9 (20)
|
27 ± 11 (40)
|
3 ± 9 (20)
|
7 ± 11 (40)
|
Tab two 10Hz
|
MADRS
|
36 ± 8 (20)
|
36 ± 8 (20)
|
35 ± 8 (20)
|
31 ± 8 (20)
|
1 ± 8 (20)
|
5 ± 8 (20)
|
BDI21
|
32 ± 9 (20)
|
33 ± 12 (20)
|
29 ± 9 (20)
|
27 ± 12 (20)
|
3 ± 9 (20)
|
6 ± 12 (20)
|
Tab two 1Hz
|
MADRS
|
36 ± 8 (20)
|
38 ± 8 (20)
|
35 ± 8 (20)
|
32 ± 9 (20)
|
1 ± 8 (20)
|
6 ± 8 (20)
|
BDI21
|
32 ± 9 (20)
|
35 ± 9 (20)
|
29 ± 9 (20)
|
27 ± 11 (20)
|
3 ± 9 (20)
|
8 ± 10 (20)
|
Höppner et al. ([2003])
|
59
|
70%
|
N/A
|
+ 3%
|
-
|
+
|
Fig two 20Hz
|
HAMD21
|
25 ± 8 (10)
|
22 ± 4 (10)
|
13 ± 8 (10)
|
14 ± 5 (10)
|
12 ± 8 (10)
|
8 ± 5 (10)
|
Fig one 20Hz
|
BDI21
|
28 ± 8 (10)
|
26 ± 7 (10)
|
22 ± 11 (10)
|
18 ± 8 (10)
|
6 ± 10 (10)
|
8 ± 8 (10)
|
Loo et al. ([2003])
|
52
|
79%
|
some
|
+ 16%
|
N/A
|
+
|
Authors
|
HAMD17
|
20 ± 4 (10)
|
24 ± 5 (9)
|
16 ± 7 (10)
|
19 ± 8 (9)
|
4 ± 6 (10)
|
5 ± 7 (9)
|
MADRS
|
33 ± 5 (10)
|
38 ± 6 (9)
|
27 ± 10 (10)
|
31 ± 14 (9)
|
6 ± 9 (10)
|
7 ± 12 (9)
|
Nahas et al. ([2003])
|
43
|
61%
|
N/A
|
+ 100%
|
N/A
|
-
|
Authors
|
HAMD28
|
33 ± 8 (12)
|
32 ± 4 (11)
|
24 ± 12 (12)
|
24 ± 12 (11)
|
9 ± 11 (12)
|
8 ± 11 (11)
|
Buchholtz et al. ([2004])
|
50
|
31%
|
N/A
|
+ 23%
|
N/A
|
+
|
Authors
|
HAMD17
|
24 ± 5 (7)
|
26 ± 3 (6)
|
13 ± 10 (7)
|
16 ± 3 (6)
|
11 ± 9 (7)
|
10 ± 3 (6)
|
Hausmann et al. ([2004])
|
47
|
61%
|
N/A
|
N/A
|
-
|
+D1
|
Tab two
|
HAMD21
|
34 ± 4 (13)
|
32 ± 6 (25)
|
22 ± 8 (13)
|
18 ± 9 (25)
|
12 ± 7 (13)
|
14 ± 8 (25)
|
BDI13
|
31 ± 12 (13)
|
32 ± 10 (25)
|
21 ± 14 (13)
|
17 ± 12 (25)
|
10 ± 13 (13)
|
15 ± 11 (25)
|
Holtzheimer et al. ([2004])
|
43
|
47%
|
+
|
-
|
-
|
-
|
Tab two
|
HAMD17
|
21 ± 6 (8)
|
23 ± 5 (7)
|
15 ± 3 (8)
|
15 ± 3 (7)
|
6 ± 5 (8)
|
8 ± 4 (7)
|
BDI21
|
28 ± 11 (8)
|
30 ± 10 (7)
|
22 ± 2 (8)
|
24 ± 3 (7)
|
6 ± 10 (8)
|
6 ± 9 (7)
|
Kauffmann et al. ([2004])
|
52
|
92%
|
+
|
N/A
|
N/A
|
+
|
Text
|
HAMD21
|
18 ± 5 (5)
|
22 ± 6 (7)
|
12 ± 4 (5)
|
11 ± 8 (7)
|
6 ± 4 (5)
|
11 ± 7 (7)
|
Koerselman et al. ([2004])
|
52
|
56%
|
N/A
|
N/A
|
N/A
|
+
|
Tab four
|
HAMD17
|
26 ± 6 (26)
|
26 ± 4 (26)
|
22 ± 7 (24)
|
21 ± 7 (25)
|
4 ± 7 (25)
|
5 ± 6 (26)
|
Mosimann et al. ([2004])
|
62
|
42%
|
+
|
+ 17%
|
N/A
|
+
|
Tab three
|
HAMD21
|
24 ± 7 (9)
|
28 ± 5 (15)
|
20 ± 7 (9)
|
23 ± 7 (15)
|
4 ± 7 (9)
|
5 ± 6 (15)
|
BDI21
|
28 ± 11 (9)
|
30 ± 9 (15)
|
23 ± 11 (9)
|
24 ± 13 (15)
|
5 ± 11 (9)
|
6 ± 12 (15)
|
Poulet et al. ([2004])
|
43
|
47%
|
N/A
|
N/A
|
N/A
|
+D1
|
Authors
|
MADRS
|
36 ± 7 (9)
|
33 ± 5 (10)
|
17 ± 9 (9)
|
16 ± 8 (10)
|
19 ± 8 (9)
|
17 ± 7 (10)
|
BDI13
|
18 ± 6 (9)
|
21 ± 8 (10)
|
11 ± 7 (9)
|
14 ± 7 (10)
|
7 ± 7 (9)
|
7 ± 8 (10)
|
Rossini et al. ([2005])a
|
47
|
80%
|
-
|
-
|
-
|
+D1
|
Tab two
|
HAMD21
| | | | |
8 ± 7 (47)
|
13 ± 7 (49)
|
Rumi et al. ([2005])
|
39
|
85%
|
N/A
|
N/A
|
-
|
+
|
Fig two
|
MADRS
|
39 ± 8 (24)
|
38 ± 8 (22)
|
28 ± 12 (24)
|
14 ± 11 (22)
|
11 ± 11 (24)
|
24 ± 10 (22)
|
Su et al. ([2005])
|
43
|
73%
|
+
|
+ 17%
|
-
|
+
|
All (Tab two)
|
HAMD21
|
23 ± 5 (10)
|
24 ± 7 (20)
|
19 ± 8 (10)
|
11 ± 7 (20)
|
4 ± 7 (10)
|
13 ± 7 (20)
|
BDI21
|
33 ± 10 (10)
|
31 ± 9 (20)
|
29 ± 15 (10)
|
16 ± 10 (20)
|
4 ± 13 (10)
|
15 ± 10 (20)
|
Avery et al. ([2006])
|
44
|
54%
|
+
|
-
|
-
|
+
|
Tab one, Text
|
HAMD17
|
24 ± 3 (33)
|
24 ± 4 (35)
|
20 ± 6 (33)
|
16 ± 8 (35)
|
4 ± 5 (33)
|
8 ± 7 (35)
|
BDI21
|
28 ± 8 (33)
|
28 ± 9 (35)
|
24 ± 8 (33)
|
17 ± 13 (35)
|
4 ± 8 (33)
|
11 ± 12 (35)
|
Fitzgerald et al. ([2006])
|
45
|
62%
|
+
|
+ 16%
|
-
|
+
|
Authors, Tab two
|
HAMD17
|
20 ± 5 (22)
|
23 ± 7 (25)
|
17 ± 6 (22)
|
16 ± 7 (25)
|
3 ± 6 (22)
|
7 ± 7 (25)
|
BDI21
|
29 ± 10 (22)
|
29 ± 10 (25)
|
22 ± 14 (22)
|
18 ± 10 (25)
|
7 ± 12 (22)
|
11 ± 10 (25)
|
MADRS
|
34 ± 6 (22)
|
34 ± 6 (25)
|
31 ± 8 (22)
|
26 ± 10 (25)
|
3 ± 7 (22)
|
8 ± 9 (25)
|
Garcia-Toro et al. ([2006])
|
48
|
55%
|
+
|
-
|
-
|
+
|
Tab two
|
HAMD21
|
25 ± 7 (10)
|
27 ± 5 (10)
|
24 ± 8 (10)
|
20 ± 8 (10)
|
1 ± 8 (10)
|
7 ± 7 (10)
|
Januel et al. ([2006])
|
38
|
78%
|
-
|
-
|
N/A
|
-
|
Tab one
|
HAMD17
|
22 ± 3 (16)
|
22 ± 4 (11)
|
17 ± 5 (16)
|
10 ± 6 (11)
|
5 ± 4 (16)
|
12 ± 5 (11)
|
Anderson et al. ([2007])
|
47
|
55%
|
some
|
N/A
|
N/A
|
+
|
Tab one
|
MADRS
|
28 ± 7 (14)
|
27 ± 4 (11)
|
23 ± 10 (14)
|
15 ± 10 (11)
|
5 ± 9 (14)
|
12 ± 9 (11)
|
Bortolomasi et al. ([2007])
|
56
|
58%
|
N/A
|
+ 16%
|
N/A
|
+
|
Fig two
|
HAMD24
|
22 ± 4 (7)
|
25 ± 8 (12)
|
18 ± 5 (7)
|
11 ± 10 (12)
|
4 ± 5 (7)
|
14 ± 9 (12)
|
Fig one
|
BDI21
|
27 ± 5 (7)
|
26 ± 7 (12)
|
22 ± 6 (7)
|
12 ± 10 (12)
|
5 ± 6 (7)
|
14 ± 9 (12)
|
Herwig et al. ([2007])
|
50
|
60%
|
some
|
+ 6%
|
N/A
|
+D1
|
Tab one
|
HAMD21
|
23 ± 5 (65)
|
25 ± 5 (62)
|
14 ± 8 (65)
|
14 ± 6 (62)
|
9 ± 7 (59)
|
11 ± 6 (57)
|
Tab two
|
BDI21
|
27 ± 10 (65)
|
27 ± 9 (62)
|
18 ± 10 (65)
|
16 ± 9 (62)
|
9 ± 10 (59)
|
11 ± 9 (57)
|
MADRS
|
27 ± 6 (65)
|
28 ± 7 (62)
|
16 ± 9 (65)
|
17 ± 8 (62)
|
11 ± 8 (59)
|
11 ± 8 (57)
|
Loo et al. ([2007])
|
48
|
47%
|
-
|
+ 11%
|
-
|
+
|
Tab two
|
HAMD17
|
21 ± 4 (19)
|
19 ± 4 (19)
|
15 ± 7 (19)
|
12 ± 6 (19)
|
6 ± 6 (19)
|
7 ± 5 (19)
|
BDI21
|
34 ± 8 (19)
|
27 ± 8 (19)
|
27 ± 10 (19)
|
18 ± 10 (19)
|
7 ± 9 (19)
|
9 ± 9 (19)
|
MADRS
|
33 ± 4 (19)
|
30 ± 4 (19)
|
27 ± 10 (19)
|
19 ± 8 (19)
|
6 ± 9 (19)
|
11 ± 7 (19)
|
O’Reardon et al. ([2007])
|
48
|
53%
|
some
|
-
|
-
|
-
|
Tab one
|
HAMD17
|
23 ± 4 (146)
|
23 ± 3 (155)
|
19 ± 6 (146)
|
17 ± 6 (155)
|
4 ± 5 (146)
|
6 ± 5 (155)
|
MADRS
|
34 ± 6 (146)
|
33 ± 6 (155)
|
30 ± 10 (146)
|
27 ± 11 (155)
|
4 ± 9 (146)
|
6 ± 10 (155)
|
Stern et al. ([2007])
|
53
|
-
|
some
|
-
|
-
|
-
|
All (Tab three)
|
HAMD21
|
27 ± 3 (15)
|
28 ± 4 (30)
|
27 ± 4 (14)
|
19 ± 8 (28)
|
0 ± 4 (14)
|
9 ± 7 (29)
|
10Hz
|
27 ± 3 (15)
|
28 ± 3 (10)
|
27 ± 4 (14)
|
15 ± 6 (10)
|
0 ± 4 (14)
|
13 ± 5 (10)
|
1Hz L
|
27 ± 3 (15)
|
28 ± 4 (10)
|
27 ± 4 (14)
|
28 ± 6 (8)
|
0 ± 4 (14)
|
0 ± 5 (9)
|
1Hz R
|
27 ± 3 (15)
|
28 ± 4 (10)
|
27 ± 4 (14)
|
16 ± 5 (10)
|
0 ± 4 (14)
|
12 ± 5 (10)
|
Bretlau et al. ([2008])
|
55
|
62%
|
some
|
N/A
|
-
|
+D1
|
Tab two
|
HAMD17
|
25 ± 3 (23)
|
25 ± 3 (22)
|
19 ± 5 (23)
|
16 ± 4 (22)
|
6 ± 4 (23)
|
9 ± 4 (22)
|
Mogg et al. ([2008])
|
54
|
63%
|
some
|
+ 2%
|
N/A
|
+
|
Authors
|
HAMD17
|
22 ± 5 (30)
|
21 ± 5 (29)
|
20 ± 8 (29)
|
16 ± 9 (28)
|
2 ± 7 (30)
|
5 ± 8 (28)
|
BDI-II21
|
36 ± 10 (30)
|
38 ± 11 (29)
|
31 ± 15 (26)
|
26 ± 15 (28)
|
5 ± 13 (28)
|
12 ± 14 (28)
|