Toward a new computer-based and easy-to-use tool for the objective measurement of motivational states in humans: a pilot study
© Aouizerate et al. 2014
Received: 10 February 2014
Accepted: 18 July 2014
Published: 11 August 2014
The experimental methods currently used for assessing motivational processes in humans have two major limitations. Some of them rely on global subjective assessments while others evaluate these processes using food-related tasks often coupled with functional neuroimaging techniques that have however limited availability and important associated costs. Here we propose a novel experimental computer-generated and easy-to-use tool primarily based on the presentation of food images and designed to provide a quantitative and objective measurement of motivational states in humans.
Two tasks evaluating respectively visual and time discrimination capacities were developed and tested on a sample of 30 healthy subjects. The subjects were asked to compare a food stimulus (food picture in color) and its devalued counterpart (same image in grayscale), at each trial, assessing either the size (task A) or the duration of presentation (task B). Geometric figures presented in color or grayscale were used as controls. The subjects were invited to perform tasks A and B during three separate experimental sessions, one under fasting and two under satiety.
Relative to their devalued counterparts, the food images were judged significantly greater in size and shorter in time of presentation in fasting than in satiety. In fasting, the size and the time of presentation for the food images were respectively estimated significantly greater and shorter than for the control images when compared to their respective devalued counterparts. Conversely, there was no overall change in the perception of size or duration of presentation for the control images between fasting and satiety conditions.
Our findings support that hunger specifically affects the perception of visual food stimuli, and suggest that this novel computer-based test is potentially useful for the study of motivational states in human diseases that are characterized by serious disturbances in reward processing.
KeywordsMotivation Computer-based tasks Food images Psychophysics
Given the increasing prevalence of highly disabling pathologies, such as major depression, addiction and obesity, in which reward function is especially disrupted (Eaton et al. ; Merikangas and McClair ; Wang et al. ), there is a significant need for an easy-to-use instrumental method designed to provide an accurate measurement of motivational states in humans.
Motivation (i.e. wanting), as one of the two components of reward beside the hedonic experience and sensory pleasure (i.e. liking), relies on the brain process involved in the attribution of incentive salience and that generates the desire to consume appetitive food (Berridge ; Berridge ; Finlayson et al. ; Finlayson and Dalton ; Cota et al. ; Piazza et al. ). The motivation to obtain and eat food is modulated by the sensations of hunger, as reflective of the physiological need to introduce calories (Berridge ; Berridge ; Finlayson et al. ; Finlayson and Dalton ; Cota et al. ; Piazza et al. ).
Several methodological approaches have been used to study motivational processes. Some clinical investigations have tried to explore time experience (e.g. how time passes slowly or quickly) or judgement (e.g. how the duration of a given timespan is estimated or produced), as indicative of the degree of motivation, which is expected to be low when time is perceived long (Mezey and Cohen ; Wyrick and Wyrick ; Bschor et al. ). However, these studies have some limitations due to the frequent use of subjective assessment methods. Some authors have instead examined the processing of the motivational value of food visual cues (Stoeckel et al. ; Stoeckel et al. ). Such experimental paradigms coupled with functional neuroimaging allow objectively identifying the anatomofunctional correlates of the internal affective state. However, an important drawback is the limited availability and costly procedures associated with functional neuroimaging. There are other computer-based tests that primarily refer to: i) food reinforcement tasks for the study of motivated responses and effort toward food (Epstein et al. ; Giesen et al. ); ii) food tasting tasks for the evaluation of the hedonic experience and pleasantness elicited by food intake (Born et al. ; Cooke et al. ); and, iii) visual probe tasks with food images for the exploration of cognitive aspects and especially the attentional capture according to the motivational characteristics of food pictures (Di Pellegrino et al. ; Nijs et al. ). Thus, to date little attention has been paid to methods assessing motivational states in relation with the perception. While the manipulation of the emotional valence of words has recently been documented to create substantial changes in the size or time perception (Ode et al. ), the perceptual processing of motivationally significant stimuli such as food, which could putatively be linked to hunger levels, has not been investigated.
Therefore, our pilot study had as objective the development and use of a new experimental computer-generated and easy-to-use test based on the presentation of visual food cues for the objective and quantitative measurement of motivational states in humans. We explored the influence of both incentive salience and physiological hunger on the visual and time perception. To this purpose, we recruited normal-weight, healthy subjects to perform two behavioral tasks, named task A and task B. These tasks respectively challenged visual and time discrimination capacities between two stimuli, a food image in color (“F”) and its devalued counterpart in grayscale (“D”) under either fasting or satiety conditions. Geometric figures in color (“C”) and graycale (“D”) were used as controls. We hypothesized that fasting specifically causes changes in the perception of either the size or the presentation duration of the food images. Measurements of perceptual changes were based on the assessment of either the point of subjective equality (PSE) (i.e. the ratio “F”/“D” or “C”/“D” for which the stimulus “F” or “C” was judged equal to “D” in terms of size or presentation time) or the percentage of subjective discrimination (PSD) (i.e. the percentage of responses where the stimulus “F” or “C” was judged greater than “D” during the trials where the stimulus “F” or “C” was physically equal to “D”, in terms of size or duration of presentation). Our study demonstrates that the subjects perceived food, but not control, images bigger in size and shorter in duration of presentation in fasting as compared to satiety. These data thus suggest that this novel computer-based test easily allows assessing quantitatively and objectively motivational states in humans, representing a potentially useful tool for the study of behavioral responses in subjects suffering from pathologies in which motivational states are altered.
Hunger levels of the study population and appetitive properties of food images
Visual analogue scales (VAS) were used to assess both hunger levels and attractiveness of the food images shown to the subjects recruited for the study. As expected, assessment of hunger levels revealed profound differences across fasting and satiety conditions [condition effect, F(2,58) = 143.07, p < 0.0001]. Hunger scores were significantly higher during the fasting session than during the satiety sessions (p < 0.0001). Ratings of appetitive properties of food pictures on VAS showed a mean score of 6.39 (±sem = 0.45). Additionally, there was no significant difference in the appetitive value of the stimuli “F” when assessed at the end of the experimental session in either fasting or satiety [condition effect, F(1,28) = 0.04, p > 0.85]. Therefore, the appetitive properties of the stimuli “F” were not estimated greater in fasting than in satiety.
Visual and time perceptions changes in response to hunger levels
Given the absence of significant difference in either the PSE or PSD for both images “F” and “C” between the two experimental sessions under satiety, the PSE and PSD calculated for either the stimuli “F” or “C” in the two satiety sessions were combined.
For task B, measurements of the PSE for the stimuli “F” and “C” varied differently across fasting and satiety conditions [stimulus x condition interaction, F(1,26) = 4.34, p < 0.05]. The PSE for the images “F” had a positive value on the logarithmic scale in fasting (Figure 1B). In other words, the subjects considered the stimuli “F” equal in time of presentation to their devalued counterparts “D” while the stimuli “F” were in reality greater in time of presentation than “D”. Therefore, in fasting, the subjects underestimated the duration of presentation of the stimuli “F” when compared to their devalued counterparts “D”. Opposite results were observed for the stimuli “C”. The PSE for the images “C” showed a negative value on the logarithmic scale in fasting (Figure 1B). This means that the subjects perceived the stimuli “C” equal in time of presentation to their devalued counterparts “D” while the stimuli “C” were in reality smaller in time of presentation than “D”. In other words, in the fasting condition, the subjects overestimated the duration of presentation of the stimuli “C” when compared to their devalued counterparts “D”. The PSE for the images “F” was significantly greater than that of the images “C” in fasting (p < 0.02) (Figure 1B). Therefore, relative to their respective devalued counterparts “D”, the duration of presentation of the stimuli “F” was estimated significantly smaller than that of the stimuli “C” under fasting. Concordant data were obtained for the PSD [stimulus x condition interaction, F(1,26) = 7.59, p < 0.01] (Figure 2B). The PSD for the images “F” was significantly smaller than that of the images “C” in fasting (p < 0.01). Additionally, there was a significantly smaller PSD under fasting than in satiety for the “F” images (p < 0.01), whereas no difference was observed for the “C” images (p > 0.72) (Figure 2B). Thus, relative to their respective devalued counterparts, the stimuli “F” under fasting were estimated shorter in duration of presentation than either “C” under fasting or “F” under satiety. However, the PSE or the PSD of the stimuli “F” did not correlate either with hunger levels in fasting [PSE: r = −0.21, p > 0.29; PSD: r = −0.08, p > 0.69] or with the appetitive properties of the images measured by VAS [PSE: r = −0.04, p > 0.85; PSD: r = 0.01, p > 0.97].
To our knowledge, this is the first study using psychophysical methods for the development of a test based on perception for the objective and quantitative assessment of motivational states in humans.
In the studied subjects, hunger levels recorded in fasting were substantially higher than those in satiety. This was paralleled by changes in the estimated size of the selected food images, which was judged greater in fasting than in satiety, when compared to their devalued counterparts. Interestingly, these changes in the perception of size were inversely related with hunger levels in fasting. Thus, more the subjects were hungry, more the size of food images was overestimated in fasting. Concomitantly, relative to their devalued counterparts, the food images was considered shorter in duration of presentation in fasting than in satiety. Conversely, perception of geometric figures used as controls remained overall stable in fasting as compared to satiety. Therefore, hunger is able to specifically produce modifications in the perception of food pictures, an effect presumably related to changes in their incentive effects. This is suggested by studies showing that visual and time perceptions are both modulated by the affective state in response to the presentation of food or word-related stimuli (Ode et al. ; Gil et al. ).
Our data illustrate the interaction between the physiological hunger and motivation. Prolonged fasting is associated with an increased activity within the hypothalamus (Tataranni et al. ) but also evokes midbrain activation in response to the anticipated experience of a forthcoming meal (DelParigi et al. ). Such activation is assumed to mediate the motivational aspects related to the expectation of food (Berridge ; Berridge ; Finlayson et al. ; Finlayson and Dalton ; Salamone and Correa ; Salamone and Correa ). The motivation is characterized by the assignment of attractive and desirable properties to an external stimulus such as a food image and it is mediated by the release of dopamine within the mesolimbic pathways (Berridge ; Berridge ; Finlayson et al. ; Finlayson and Dalton ; Salamone and Correa ; Salamone and Correa ). Interestingly, the mesencephalic dopamine system has also been described to occupy a pivotal position in the perception of time, according to the classical pacemaker-accumulator model that allows the estimation, integration and discrimination of time intervals (Buhusi and Meck ; Meck et al. ).
Our global evaluation of the appetitive value of the food images used in our study accounted for their incentive value. However, numerous functional neuroimaging studies have shown that the presentation of visual food stimuli is associated with the activation of frontal-limbic loops (Stoeckel et al. ; Stoeckel et al. ) that are highly involved in processing the hedonic significance of environmental stimuli (Krawczyk ; Phillips et al. ). Visual food stimuli do not only induce incentive, but also affective responses, which reflect the pleasantness of the sensation produced by the presentation of food images (Cabanac ; Brondel and Cabanac ). Also, our data confirm previous findings showing that the time of presentation of food images is underestimated, as compared to that of neutral pictures. Importantly, this effect is related to the pleasure provoked by the food images (Gil et al. ). Thus, although emotional responses were not specifically assessed in our study, it cannot be ruled out that hunger will affect not only the incentive, but also the hedonic characteristics of the food pictures.
The present study has some limitations. First, differently from what initially expected, the geometric figures used in our study, were overestimated in size as the food images, especially under fasting, when compared to their respective devalued counterparts. This finding is consistent with earlier studies showing that the color of a stimulus affects its size perception (Tedford et al. ; Ling and Hurlbert ). Relationships between the color and the emotional reaction elicited by the presentation of a stimulus have also been established (Valdez and Mehrabian ). Therefore, it can be assumed that the geometric figures in color relative to their devalued counterparts in grayscale could possibly acquire emotional salience, as seen for the food images, and consequently induce changes in size perception under fasting, as suggested by the effects of affective states on size estimation (Ode et al. ). Second, measurements of the PSD showed that hunger specifically induces an overestimation of the size of the viewed food images under fasting while assessments of PSE revealed similar changes in the size perception although occurring indifferently for both types of stimuli in fasting. This partial discrepancy between the PSD and PSE could be possibly due to the chosen psychophysical parameters, especially the size of the step, which might be too large for identifying with the PSE small perceptual differences between food and control stimuli in a sample of healthy subjects free from any pathology of the reward system. Thus, it might be necessary to further reduce the size of the step in order to better differentiate changes in the size perception of the food pictures from those of control images by using the PSE. An alternative explanation is the smaller number of subjects performing the task A than those participating in the task B for which the PSE and the PSD concordantly showed that under fasting the time of presentation was perceived shorter for food but not for control images. Third, the PSD is a particularly appropriate measurement derived from the responses to a large number of trials (from 200 to 350) where both stimuli “F” and “D” are equal in terms of size and duration of presentation, as those responses obtained in our study for each experimental session at the level of the entire group sample. However, this experimental variable might partially loose its accuracy when calculated individually for each participant on a smaller number of trials (from 9 to 14) during each experimental session, thereby resulting in the absence of correlation with the hunger levels or the appetitive value of the food images. Fourth, as reported above, the appetitive value of the viewed food images was rated on VAS at the end of the last experimental session in order to avoid giving the participants particular information about the exact objectives of the study, and therefore limiting biased responses to food images. However, this approach raises the question about the accuracy of a retrospective measurement of the overall appetitive properties attributed to the food pictures of the study. This might explain why i) there was no influence of fasting on the appetitive value of food images; and, ii) there was no relation with the experimental variables PSE and PSD that we used. Fifth, previous findings have shown the allocation of attentional resources in response to the salience and relevance of food-related stimuli (Di Pellegrino et al. ; Forestell et al. ; Yokum et al. ). In particular, it has been demonstrated that the attentional processing for food stimuli is influenced by fasting (Nijs et al. ; Siep et al. ; Piech et al. ). Our study assessed the accuracy of perception, as reflected by the PSE. However, we did not assess the precision of perception, which reflects, at least in part, the participant’s attentional engagement. Finally, our sample was characterized by an overrepresentation of women. This could impact our findings, as attested by differential effects of the hunger drive on hedonic responses to food pictures according to gender (Stoeckel et al. ). Interestingly, such gender effect seems to depend upon the categories of food (Stoeckel et al. ). Thus, the use of a large variety of food stimuli as done in our study might have minimized the effects of gender. However, it might be important to examine the putative presence of gender effects in future studies requiring larger samples of subjects.
The present pilot study pleads for the potential usefulness of a novel computer-based test that we have developed for the study of motivational processing of food images, allowing assessing changes in visual and time perception in humans. We showed that the accuracy of the perception depends on the appetitive properties of the food stimuli and that this is in close relation with the hunger drive. This computer-based test could therefore contribute to the characterization of disturbances in reward processes and responses to standard therapeutic strategies in subjects affected by mood, addictive disorders or obesity.
Thirty healthy subjects (11 men, 19 women), whose ages ranged from 25 to 58 years (mean age = 32.17 years ± sem = 1.78), were recruited through printed announcements and word of mouth. All the subjects were free of: i) past and current DSM-IV axis I psychiatric disorders, including drug addiction or abuse; ii) serious medical and neurological disorders; and, iii) chronic exposure to psychotropic agents and other medications affecting the physiology of the central nervous system. The Body Mass Index (BMI) calculated for each participant before entering the study was systematically comprised between 18.5 and 24.9 kg/m2 (mean BMI = 21.80 kg/m2 ± sem = 0.32). Also, the subjects had normal or corrected-to-normal vision. They were asked to abstain from alcohol drinking for at least 2 days before and throughout the study. Caffeine or tobacco use was not permitted over the last 3 hours prior to the testing in order to substantially reduce the risk for attention and memory biases. The INSERM Institutional Review Board specifically approved the present study. All the participants gave written informed consent after a complete description of the protocol. However, the subjects were unaware of the exact nature of the study. They were financially compensated for their participation in the study.
Two experimental sessions in satiety were carried out 3–4 days apart in order to ensure that the behavioral responses to the tasks remained stable over time. One additional session in fasting for 6 hours before the test was performed 3–4 days apart from those in satiety. The experimental sessions in satiety preceded or followed the one in fasting in a randomized order. When tested in satiety, the subjects consumed a calorically-defined meal (600 kcal) 15 minutes after the arrival at the laboratory. Following a one-hour period of resting, they were asked to perform tasks A and B with a 20-min time interval between tasks. The order of the tasks A and B was randomized across the experimental sessions. Before starting the first task, a visual analogue scale (VAS) was systematically completed in order to assess hunger levels. Each subject had to answer the following question: “How hungry are you?” and rate hunger levels by placing a mark on a horizontal line, 100 mm in length, anchored by the word descriptors “Not at all” on the left end (0) and “Extremely” on the right end (100). An additional VAS evaluating the appetitive properties of the viewed food pictures was administered although only at the end of the last experimental session, so that the exact objective of the study remained unknown to the participants, thereby limiting potential response bias. The following question was asked: “How much did you consider the presented food images appetitive?”. The subject was invited to place a mark on the horizontal line anchored by word descriptors similar to those cited above for the VAS assessing hunger levels. For both VAS, the score was determined by measuring the distance in millimeters from the left end of the line to the mark that the subject drew (Wewers and Lowe ; Gould et al. ).
Two experimental variables were considered as a measurement of perceptual changes that are putatively reflective of changes in motivational states. First, the point of subjective equality (PSE) calculated for each category of stimuli “F” and “C” is the ratio “F”/“D” or “C”/“D” for which the stimulus “F” or “C” was judged equal to “D” in terms of size or presentation time and it is estimated by averaging reversal points within both staircases (Jesteadt ). Second, the percentage of subjective discrimination (PSD) determined for each type of stimuli “F” and “C” corresponds to the percentage of responses where the stimulus “F” or “C” was judged greater than “D” during the trials where the stimulus “F” or “C” was physically equal to “D”, in terms of size or duration of presentation (Figure 4). This latter variable is expected to show changes in either size or time perception similar to those found with the PSE. For instance, if the PSE for the stimuli “F” has a positive value, it means that the stimuli “F” are considered equal to their devalued counterparts “D” whereas the stimuli “F” are in reality greater than “D” in either size or presentation time. Therefore, the stimuli “F” were underestimated as compared to “D”. Consequently, the corresponding PSD will have a value below 50%.
Of the study population, data of the first 6 subjects enrolled for task A that served for gradual psychophysical parameter adjustments (step size, initial ratio “F”/“D” or “C”/“D”) were excluded from the final analyses. For task B, data of 3 subjects were excluded because pictures were abnormally displayed on the computer screen when these 3 subjects passed the test.
One- and two-way ANOVAs were respectively performed for the comparison of: i) the hunger levels and appetitive values of food images between fasting and satiety conditions; and, ii) the PSE and PSD between fasting and satiety conditions according to the category of stimuli “F” and “C”. Newman-Keuls test was used for post-hoc analysis. Pearson’s test was used for correlation analyses between: 1) the hunger levels and the PSE or PSD calculated for either the stimuli “F” or “C” in the fasting condition; and, 2) the appetitive value of the stimuli “F” and the PSE or PSD calculated for the stimuli “F” in the fasting condition. Results were considered as significant at p < 0.05.
Pier Vincenzo Piazza and Daniela Cota share senior authorship.
Point of subjective equality
Percentage of subjective discrimination
Visual analogue scale
This study was supported by INSERM (D.C., P.V.P.), Fondation pour la Recherche Médicale Master fellowship (C.G.), Servier/Eutherapie laboratories, French “Fonds Français pour l′Alimentation et la Santé (B.A.) and Labex BRAIN ANR-10-LABX-43 (D.C.). All the funders had no further role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Mrs. Bert-Latrille from the GENPPHASS for helping with the pre-screening of the potential research participants. We thank the subjects who have participated in the study.
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